Xiang Wang1, Xueping Gao2, Manyi Xiao3, Luosheng Tang3, Xin Wei3, Jiexi Zeng3, Yunping Li4. 1. Cancer Research Institute, Central South University, Changsha, Hunan, China; Department of Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. 2. Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. 3. Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. 4. Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China; State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China; Eye Research Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: amyli@csu.edu.cn.
Abstract
PURPOSE: To evaluate the ability of strabismus surgery to improve the health-related quality of life (HRQOL) assessment scores of children with intermittent exotropia and their parents. METHODS: For this prospective, randomized, parallel group study, 130 children (8-17 year of age) with intermittent exotropia were recruited and randomized to undergo either corrective strabismus surgery or active monitoring without surgery. Each child was accompanied by a parent. HRQOL was assessed with 3 intermittent exotropia questionnaires (IXTQ)--the child self-report, parental proxy report, and parental self-report--administered at enrollment and 3 months after intervention. The primary outcome was change in IXTQ score after 3 months for both groups. RESULTS: At enrollment the scores of the surgery group (n = 63) and monitoring group (n = 57) did not differ significantly (P > 0.05). The sex of the reporting parent had no significant influence on the proxy or parental scores at enrollment or at 3 months (P > 0.05, multivariate analysis). Strabismus surgery significantly improved all parts of the IXTQ scores (P < 0.0001, repeated measures analysis of variance). No significant changes were found for the child scores at 3 months in the monitoring group (P = 0.33). However, the parental and proxy scores were significantly decreased (P < 0.0001). CONCLUSIONS:Corrective strabismus surgery significantly improved the HRQOL scores of the children with intermittent exotropia and their parents.
RCT Entities:
PURPOSE: To evaluate the ability of strabismus surgery to improve the health-related quality of life (HRQOL) assessment scores of children with intermittent exotropia and their parents. METHODS: For this prospective, randomized, parallel group study, 130 children (8-17 year of age) with intermittent exotropia were recruited and randomized to undergo either corrective strabismus surgery or active monitoring without surgery. Each child was accompanied by a parent. HRQOL was assessed with 3 intermittent exotropia questionnaires (IXTQ)--the child self-report, parental proxy report, and parental self-report--administered at enrollment and 3 months after intervention. The primary outcome was change in IXTQ score after 3 months for both groups. RESULTS: At enrollment the scores of the surgery group (n = 63) and monitoring group (n = 57) did not differ significantly (P > 0.05). The sex of the reporting parent had no significant influence on the proxy or parental scores at enrollment or at 3 months (P > 0.05, multivariate analysis). Strabismus surgery significantly improved all parts of the IXTQ scores (P < 0.0001, repeated measures analysis of variance). No significant changes were found for the child scores at 3 months in the monitoring group (P = 0.33). However, the parental and proxy scores were significantly decreased (P < 0.0001). CONCLUSIONS: Corrective strabismus surgery significantly improved the HRQOL scores of the children with intermittent exotropia and their parents.
Authors: Laura Liebermann; David A Leske; Yolanda S Castañeda; Sarah R Hatt; Suzanne M Wernimont; Christina S Cheng; Eileen E Birch; Jonathan M Holmes Journal: J AAPOS Date: 2016-07-02 Impact factor: 1.220