A Yenigun1, H Karamanli2. 1. Department of Otorhinolaryngology,Faculty of Medicine,Bezmialem Vakif University,Istanbul,Turkey. 2. Department of Respiratory Medicine,Faculty of Medicine,Mevlana University,Konya,Turkey.
Abstract
OBJECTIVE: To investigate the neutrophil-to-lymphocyte ratio and sleep apnoea severity relationship. METHODS: Patients (n = 178) were assigned to five groups according to apnoea-hypopnea indices and continuous positive airway pressure use. White blood cell, neutrophil, lymphocyte and neutrophil-to-lymphocyte ratio values were compared for each group. RESULTS: The neutrophil-to-lymphocyte ratio values of severe obstructive sleep apnoea syndrome patients (group 4) were significantly higher than those of: control patients (group 1), mild obstructive sleep apnoea syndrome patients (group 2) and patients treated with continuous positive airway pressure (group 5) (p = 0.008, p = 0.008 and p = 0.003). Minimum oxygen saturation values of group 4 were significantly lower than those of groups 1, 2 and 5 (p = 0.0005, p = 0.011 and p = 0.001). There was a positive correlation between apnoea-hypopnea index and neutrophil-to-lymphocyte ratio (r = 0.758, p = 0.034), and a negative correlation between apnoea-hypopnea index and minimum oxygen saturation (r = -0.179, p = 0.012). CONCLUSION: Neutrophil-to-lymphocyte ratio may be used to determine disease severity, complementing polysomnography.
OBJECTIVE: To investigate the neutrophil-to-lymphocyte ratio and sleep apnoea severity relationship. METHODS:Patients (n = 178) were assigned to five groups according to apnoea-hypopnea indices and continuous positive airway pressure use. White blood cell, neutrophil, lymphocyte and neutrophil-to-lymphocyte ratio values were compared for each group. RESULTS: The neutrophil-to-lymphocyte ratio values of severe obstructive sleep apnoea syndromepatients (group 4) were significantly higher than those of: control patients (group 1), mild obstructive sleep apnoea syndromepatients (group 2) and patients treated with continuous positive airway pressure (group 5) (p = 0.008, p = 0.008 and p = 0.003). Minimum oxygen saturation values of group 4 were significantly lower than those of groups 1, 2 and 5 (p = 0.0005, p = 0.011 and p = 0.001). There was a positive correlation between apnoea-hypopnea index and neutrophil-to-lymphocyte ratio (r = 0.758, p = 0.034), and a negative correlation between apnoea-hypopnea index and minimum oxygen saturation (r = -0.179, p = 0.012). CONCLUSION: Neutrophil-to-lymphocyte ratio may be used to determine disease severity, complementing polysomnography.
Authors: Moh'd Al-Halawani; Christian Kyung; Fei Liang; Ian Kaplan; Jane Moon; Guerrier Clerger; Bruce Sabin; Andrea Barnes; Mohammad Al-Ajam Journal: J Clin Sleep Med Date: 2020-01-13 Impact factor: 4.062
Authors: Glaucylara Reis Geovanini; Rui Wang; Jia Weng; Nancy S Jenny; Steven Shea; Matthew Allison; Peter Libby; Susan Redline Journal: Ann Am Thorac Soc Date: 2018-08