| Literature DB >> 26235036 |
Xingyu Li1, Lulu Wang2, Tiejun Li3, Bo You4, Yin Shan4, Si Shi4, Li Qian5, Xiaolei Cao6.
Abstract
Stathmin 1 (STMN1) is an important molecule in regulating cellular microtubule dynamics and promoting microtubule depolymerization in interphase and late mitosis. Evidences showed that STMN1 was up-regulated in many cancers, but there was no report about the roles of STMN1 in human cutaneous squamous cell carcinoma (cSCC). Here, we confirmed significant upregulation of STMN1 in cSCC tissues and cell lines compared with non-tumor counterparts. STMN1 upregulation was associated with the proliferation, migration, invasion and apoptosis of cSCC cells. The results suggested that STMN1 may play an important role in the development and tumor progression of cSCC.Entities:
Keywords: A431; Cutaneous squamous cell carcinoma (cSCC); Stathmin 1 (STMN1); siRNA
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Year: 2015 PMID： 26235036 DOI： 10.1016/j.prp.2015.07.009
Source DB: PubMed Journal: Pathol Res Pract ISSN： 0344-0338 Impact factor: 3.250