| Literature DB >> 26234562 |
Shaochen Fan1,2, Chengjin Zhao3, Li Zhang4, Shirong Dai3, Jianbing Ren3, Xiubing Zhang3, Na Ban4, Xiaojuan He4, Lixiang Yang5, Zhen Bao5, Wenjuan Chen4, Jie Sun4, Yilu Gao6,7, Tao Tao8.
Abstract
The prognosis of glioma patients is generally poor, so it is urgent to find out the underlying molecular mechanisms. PFTK1 is a member of cyclin-dependent kinases (Cdks) family and has been reported to contribute to tumor migration and invasion. In this study, we aimed to explore the expression and function in human glioma. Western blot and immunohistochemistry were used to evaluate the expression of PFTK1. PFTK1 expression was higher in glioma tissues compared with normal brain tissues, and its level was associated with the WHO grade in Western blot analysis. The suppression of PFTK1 expression by RNA interference was shown to inhibit the migration of glioma cells. Knockdown of PFTK1 increases E-cadherin expression and decreases vimentin expression. These data show that PFTK1 may participate in the pathogenic process of glioma, suggesting that PFTK1 can become a potential therapeutic strategy for gastric cancer.Entities:
Keywords: E-cadherin; Glioma; Knockdown; Migration; PFTK1
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Year: 2015 PMID： 26234562 DOI： 10.1007/s12031-015-0600-z
Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444