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Literature DB >> 26233721

Association of the IRF5 rs2070197 polymorphism with systemic lupus erythematosus: a meta-analysis.

Yuan Li¹, Si Chen, Ping Li, Ziyan Wu, Jing Li, Bin Liu, Fengchun Zhang, Yongzhe Li.

Abstract

The aim of this study was to explore whether the interferon regulatory factor 5 (IRF5) gene rs2070197 polymorphism was associated with systemic lupus erythematosus (SLE) in multiple ethic populations. A meta-analysis was conducted on the C allele of the IRF5 rs2070197 polymorphism. A total of 7 published case-control studies with 12 comparisons involving 8171 SLE patients and 8904 controls were available for this meta-analysis. This meta-analysis demonstrated the IRF5 rs2070197 polymorphism conferred susceptibility to SLE in all subjects (odds ratio (OR) = 2.128, 95 % confidence interval (CI): 1.856-2.441, P < 0.001) without inter-study heterogeneity. The IRF5 rs2070197 polymorphism was identified as risk factors for SLE in Caucasian populations (OR 1.82, 95 % CI 1.70-1.96), but it had no effects (monomorphic) in Asians. Large-scale multicenter epidemiological studies in selected populations with other risk factors were urgently required.

Entities: Disease Gene Mutation Species

Mesh：

Substances：

Year: 2015 PMID： 26233721 DOI： 10.1007/s10067-015-3036-5

Source DB: PubMed Journal: Clin Rheumatol ISSN： 0770-3198 Impact factor: 2.980

32 in total

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Journal: Proc Natl Acad Sci U S A Date: 2010-02-22 Impact factor: 11.205

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Journal: Nat Genet Date: 2006-04-16 Impact factor: 38.330

4. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.

Authors: Akinori Takaoka; Hideyuki Yanai; Seiji Kondo; Gordon Duncan; Hideo Negishi; Tatsuaki Mizutani; Shin-Ichi Kano; Kenya Honda; Yusuke Ohba; Tak W Mak; Tadatsugu Taniguchi
Journal: Nature Date: 2005-01-23 Impact factor: 49.962

5. Promoter insertion/deletion in the IRF5 gene is highly associated with susceptibility to systemic lupus erythematosus in distinct populations, but exerts a modest effect on gene expression in peripheral blood mononuclear cells.

Authors: Sara E Löfgren; Hong Yin; Angelica M Delgado-Vega; Elena Sanchez; Susanna Lewén; Bernardo A Pons-Estel; Torsten Witte; Sandra D'Alfonso; Norberto Ortego-Centeno; Javier Martin; Marta E Alarcón-Riquelme; Sergey V Kozyrev
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Authors: Geoffrey Hom; Robert R Graham; Barmak Modrek; Kimberly E Taylor; Ward Ortmann; Sophie Garnier; Annette T Lee; Sharon A Chung; Ricardo C Ferreira; P V Krishna Pant; Dennis G Ballinger; Roman Kosoy; F Yesim Demirci; M Ilyas Kamboh; Amy H Kao; Chao Tian; Iva Gunnarsson; Anders A Bengtsson; Solbritt Rantapää-Dahlqvist; Michelle Petri; Susan Manzi; Michael F Seldin; Lars Rönnblom; Ann-Christine Syvänen; Lindsey A Criswell; Peter K Gregersen; Timothy W Behrens
Journal: N Engl J Med Date: 2008-01-20 Impact factor: 91.245

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Authors: Timothy B Niewold; Daniel N Clark; Rafah Salloum; Brian D Poole
Journal: J Biomed Biotechnol Date: 2010-06-29

8. Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.

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Journal: J Immunol Date: 2009-01-01 Impact factor: 5.422

9. Different genetic effects of interferon regulatory factor 5 (IRF5) polymorphisms on systemic lupus erythematosus in a Korean population.

Authors: Hyoung Doo Shin; Il Kim; Chan-Bum Choi; Soo Ok Lee; Hye Won Lee; Sang-Cheol Bae
Journal: J Rheumatol Date: 2008-10-01 Impact factor: 4.666

10. STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk.

Authors: A-K Abelson; A M Delgado-Vega; S V Kozyrev; E Sánchez; R Velázquez-Cruz; N Eriksson; J Wojcik; M V P Linga Reddy; G Lima; S D'Alfonso; S Migliaresi; V Baca; L Orozco; T Witte; N Ortego-Centeno; H Abderrahim; B A Pons-Estel; C Gutiérrez; A Suárez; M F González-Escribano; J Martin; M E Alarcón-Riquelme
Journal: Ann Rheum Dis Date: 2008-11-19 Impact factor: 19.103

4 in total