Michael von Rhein1, Andreas Buchmann2, Cornelia Hagmann3, Hitendu Dave4, Vera Bernet5, Ianina Scheer6, Walter Knirsch7, Beatrice Latal8. 1. Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Developmental Pediatrics, SPZ, Kantonsspital Winterthur, Winterthur, Switzerland; Children's Research Center, University Children's Hospital, Zurich, Switzerland. 2. Department of Neurology, University Hospital Zurich, Zurich, Switzerland. 3. Department of Neonatology, University Hospital Zurich, Zurich, Switzerland. 4. Congenital Cardiovascular Surgery, University Children's Hospital Zurich, Zurich, Switzerland. 5. Children's Research Center, University Children's Hospital, Zurich, Switzerland; Department of Neonatology and Intensive Care, University Children's Hospital Zurich, Zurich, Switzerland. 6. Diagnostic Imaging, University Children's Hospital, Zurich, Switzerland. 7. Children's Research Center, University Children's Hospital, Zurich, Switzerland; Cardiology, University Children's Hospital, Zurich, Switzerland. 8. Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Children's Research Center, University Children's Hospital, Zurich, Switzerland.
Abstract
OBJECTIVES: To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth. STUDY DESIGN: Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions. RESULTS: Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001). CONCLUSIONS: Infants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.
OBJECTIVES: To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth. STUDY DESIGN: Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions. RESULTS: Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001). CONCLUSIONS:Infants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.
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