Shu-Chen Kuo1, Shih-Wei Lai2, Hung-Chang Hung3, Chih-Hsin Muo4, Shih-Chang Hung5, Ling-Ling Liu6, Chia-Wei Chang7, Yueh-Juen Hwu8, Shieh-Liang Chen9, Fung-Chung Sung10. 1. Department of Nursing, Lo-Sheng Sanatorium and Hospital, Ministry of Health and Welfare, New Taipei, 242, Taiwan; Department of Business Administration, Asia University, Taichung, 413, Taiwan. 2. College of Medicine, China Medical University, Taichung, 404, Taiwan; Department of Family Medicine, China Medical University Hospital, Taichung, 404, Taiwan. 3. Department of Internal Medicine, Nantou Hospital, Ministry of Health and Welfare, Nantou, 540, Taiwan. 4. Management Office for Health Data, China Medical University Hospital, Taichung, 404, Taiwan. 5. Department of Emergency Medicine, Nantou Hospital, Ministry of Health and Welfare, Nantou, 540, Taiwan. Electronic address: shihchan@gmail.com. 6. Department of Emergency Medicine, Nantou Hospital, Ministry of Health and Welfare, Nantou, 540, Taiwan. 7. Department of Neurology, Nantou Hospital, Ministry of Health and Welfare, Nantou, 540, Taiwan. 8. College of Nursing, Central Taiwan University of Science and Technology, Taichung, 406, Taiwan. 9. Department of Business Administration, Asia University, Taichung, 413, Taiwan. 10. Management Office for Health Data, China Medical University Hospital, Taichung, 404, Taiwan; Institute of Clinical Medical Science, China Medical University, Taichung, 404, Taiwan.
Abstract
AIMS: Most diabetes mellitus (DM) patients have several comorbidities; the correlation of these comorbidities with dementia in DM requires clarification. METHODS: Using claims data from Taiwan National Health Insurance, we identified 33,709 DM adults before the year 2000 and randomly selected 67,066 non-DM patients matched by sex and age. Subjects were followed until diagnosis with dementia, excluded due to death/withdrawal from the insurance program, or followed until 2011. We compared the incidence and hazard ratio (HR) for dementia in both cohorts. RESULTS: Comorbidities were more prevalent in DM patients, including hypertension, hyperlipidemia, stroke, coronary artery and/or kidney disease. The HR was higher for the DM cohort with comorbidities than those without: 1.88 vs. 1.46 with hypertension; 1.56 vs. 1.39 with hyperlipidemia; 1.73 vs. 1.37 with coronary artery disease; 2.36 vs. 2.29 with stroke and 1.88 vs. 1.50 with kidney disease. The HR for dementia in diabetics rose from 1.41 in those without comorbidities to 2.49 in those with ≥4 comorbidities. In the DM cohort, HR was 1.22 for non-insulin-users and 1.41 for insulin-users, and 1.49 for type 1 DM and 1.23 for type 2 DM. CONCLUSION: Diabetic patients have an elevated risk of dementia, and comorbidity increases this risk.
AIMS: Most diabetes mellitus (DM) patients have several comorbidities; the correlation of these comorbidities with dementia in DM requires clarification. METHODS: Using claims data from Taiwan National Health Insurance, we identified 33,709 DM adults before the year 2000 and randomly selected 67,066 non-DMpatients matched by sex and age. Subjects were followed until diagnosis with dementia, excluded due to death/withdrawal from the insurance program, or followed until 2011. We compared the incidence and hazard ratio (HR) for dementia in both cohorts. RESULTS: Comorbidities were more prevalent in DMpatients, including hypertension, hyperlipidemia, stroke, coronary artery and/or kidney disease. The HR was higher for the DM cohort with comorbidities than those without: 1.88 vs. 1.46 with hypertension; 1.56 vs. 1.39 with hyperlipidemia; 1.73 vs. 1.37 with coronary artery disease; 2.36 vs. 2.29 with stroke and 1.88 vs. 1.50 with kidney disease. The HR for dementia in diabetics rose from 1.41 in those without comorbidities to 2.49 in those with ≥4 comorbidities. In the DM cohort, HR was 1.22 for non-insulin-users and 1.41 for insulin-users, and 1.49 for type 1 DM and 1.23 for type 2 DM. CONCLUSION:Diabeticpatients have an elevated risk of dementia, and comorbidity increases this risk.
Authors: Liora G Rodill; Lieza G Exalto; Paola Gilsanz; Geert Jan Biessels; Charles P Quesenberry; Rachel A Whitmer Journal: Alzheimer Dis Assoc Disord Date: 2018 Apr-Jun Impact factor: 2.703
Authors: Peter Riederer; Amos D Korczyn; Sameh S Ali; Ovidiu Bajenaru; Mun Seong Choi; Michael Chopp; Vesna Dermanovic-Dobrota; Edna Grünblatt; Kurt A Jellinger; Mohammad Amjad Kamal; Warda Kamal; Jerzy Leszek; Tanja Maria Sheldrick-Michel; Gohar Mushtaq; Bernard Meglic; Rachel Natovich; Zvezdan Pirtosek; Martin Rakusa; Melita Salkovic-Petrisic; Reinhold Schmidt; Angelika Schmitt; G Ramachandra Sridhar; László Vécsei; Zyta Beata Wojszel; Hakan Yaman; Zheng G Zhang; Tali Cukierman-Yaffe Journal: J Neural Transm (Vienna) Date: 2017-08-01 Impact factor: 3.575