Kristine Phillips1,2, Ann Taylor3,4, Philip J Mease3,4, Lee S Simon3,4, Philip G Conaghan3,4, Ernest H Choy3,4, Jasvinder A Singh3,4, Vibeke Strand3,4, Laure Gossec3,4, Ulrike Kaiser3,4, Marteen de Wit3,4, Raymond Ostelo3,4, Lara Maxwell3,4, Peter S Tugwell3,4. 1. From the Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA; Cardiff University, Cardiff, UK; Swedish Medical Center and University of Washington, Seattle, Washington, USA; SDG LLC, Cambridge, Massachusetts, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; University of Alabama at Birmingham, Birmingham, Alabama; Division of Immunology/Rheumatology, Stanford University, Palo Alto, California, USA; University Hospital Carl Gustav Carus, Dresden, Germany; Universite Pierre et Marie Curie and APHP, Department of Rheumatology, Pitie-Salpetriere Hospital, Paris, France; EMGO Institute for Health and Care Research, Department of Health Sciences, VU University, and Department of Epidemiology and Biostatistics, VU University Medical Center, VU Medical Center, Amsterdam, The Netherlands. kphill@umich.edu. 2. K. Phillips, MD, PhD, Department of Internal Medicine, University of Michigan; A. Taylor, PhD, MSc, Cardiff University; P.J. Mease, MD, Swedish Medical Center and University of Washington; L.S. Simon, MD, SDG LLC; P.G. Conaghan, MBBS, PhD, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit; E.H. Choy, MD, FRCP, Department of Medicine, Cardiff University School of Medicine; J.A. Singh, MD, MPH, University of Alabama at Birmingham; V. Strand, MD, Division of Immunology/Rheumatology, Stanford University; L. Gossec, MD, PhD, Universite Pierre et Marie Curie and APHP, Department of Rheumatology, Pitie-Salpetriere Hospital; U. Kaiser, Dr, University Hospital Carl Gustav Carus, Dresden, Germany; M. de Wit, PhD, VU Medical Center; R.W. Ostelo, MD, EMGO Institute for Health and Care Research, Department of Health Sciences, VU University; and Department of Epidemiology and Biostatistics, VU University Medical Center; L. Maxwell, MSc, University of Ottawa, Institute of Population Health; P.S. Tugwell, MD, MSc, University of Ottawa, Centre for Global Health. kphill@umich.edu. 3. From the Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA; Cardiff University, Cardiff, UK; Swedish Medical Center and University of Washington, Seattle, Washington, USA; SDG LLC, Cambridge, Massachusetts, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; University of Alabama at Birmingham, Birmingham, Alabama; Division of Immunology/Rheumatology, Stanford University, Palo Alto, California, USA; University Hospital Carl Gustav Carus, Dresden, Germany; Universite Pierre et Marie Curie and APHP, Department of Rheumatology, Pitie-Salpetriere Hospital, Paris, France; EMGO Institute for Health and Care Research, Department of Health Sciences, VU University, and Department of Epidemiology and Biostatistics, VU University Medical Center, VU Medical Center, Amsterdam, The Netherlands. 4. K. Phillips, MD, PhD, Department of Internal Medicine, University of Michigan; A. Taylor, PhD, MSc, Cardiff University; P.J. Mease, MD, Swedish Medical Center and University of Washington; L.S. Simon, MD, SDG LLC; P.G. Conaghan, MBBS, PhD, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit; E.H. Choy, MD, FRCP, Department of Medicine, Cardiff University School of Medicine; J.A. Singh, MD, MPH, University of Alabama at Birmingham; V. Strand, MD, Division of Immunology/Rheumatology, Stanford University; L. Gossec, MD, PhD, Universite Pierre et Marie Curie and APHP, Department of Rheumatology, Pitie-Salpetriere Hospital; U. Kaiser, Dr, University Hospital Carl Gustav Carus, Dresden, Germany; M. de Wit, PhD, VU Medical Center; R.W. Ostelo, MD, EMGO Institute for Health and Care Research, Department of Health Sciences, VU University; and Department of Epidemiology and Biostatistics, VU University Medical Center; L. Maxwell, MSc, University of Ottawa, Institute of Population Health; P.S. Tugwell, MD, MSc, University of Ottawa, Centre for Global Health.
Abstract
OBJECTIVE: A variety of authorities in pain measurement and outcome methodology met prior to the Outcome Measures in Rheumatology (OMERACT) 12 meeting in May 2014 to develop partnerships for consensus on pain outcomes. METHODS: Following overview presentations, discussion centered on pain-specific and global constructs in the domain of chronic pain. Practical issues for clinical trial implementation were also discussed. Breakout sessions were completed regarding additional details of domain constructs. A nominal group process involving all workshop participants confirmed that chronic pain outcome measures encompass a broad range of constructs and that existing scales may be inadequate for assessment in clinical trials. RESULTS: Participants endorsed that both pain intensity and pain interference are important constructs to be measured in clinical trials of chronic pain as it pertains to rheumatologic diagnoses. CONCLUSION: Further work is needed on inclusion of the patient perspective in the development of pain domains as well as Cochrane Collaboration summary of findings tables.
OBJECTIVE: A variety of authorities in pain measurement and outcome methodology met prior to the Outcome Measures in Rheumatology (OMERACT) 12 meeting in May 2014 to develop partnerships for consensus on pain outcomes. METHODS: Following overview presentations, discussion centered on pain-specific and global constructs in the domain of chronic pain. Practical issues for clinical trial implementation were also discussed. Breakout sessions were completed regarding additional details of domain constructs. A nominal group process involving all workshop participants confirmed that chronic pain outcome measures encompass a broad range of constructs and that existing scales may be inadequate for assessment in clinical trials. RESULTS: Participants endorsed that both pain intensity and pain interference are important constructs to be measured in clinical trials of chronic pain as it pertains to rheumatologic diagnoses. CONCLUSION: Further work is needed on inclusion of the patient perspective in the development of pain domains as well as Cochrane Collaboration summary of findings tables.
Authors: Alexis Ogdie; Kurt de Vlam; Iain B McInnes; Philip J Mease; Philip Baer; Tatjana Lukic; David Gruben; Kenneth Kwok; Cunshan Wang; Ming-Ann Hsu; Anna Maniccia Journal: RMD Open Date: 2020-02