| Literature DB >> 26232346 |
Hiroshi Ishii1, Tetsuro Matano2.
Abstract
Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel AIDS vaccine using a Sendai virus (SeV) vector and investigated its efficacy in a macaque AIDS model of simian immunodeficiency virus (SIV) infection. Its immunogenicity and protective efficacy have been shown, indicating that the SeV vector is a promising delivery tool for AIDS vaccines. Here, we describe the potential of SeV vector as a vaccine antigen delivery tool to induce effective immune responses against HIV-1 infection.Entities:
Keywords: AIDS vaccine; HIV; SIV; Sendai virus vector
Mesh:
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Year: 2015 PMID: 26232346 DOI: 10.1016/j.vaccine.2015.06.114
Source DB: PubMed Journal: Vaccine ISSN: 0264-410X Impact factor: 3.641