Literature DB >> 26232214

Leptin Does Not Mediate Hypertension Associated With Human Obesity.

Rebecca J Brown1, Cristina Adelia Meehan1, Phillip Gorden2.   

Abstract

Hypertension and obesity are known to be linked, with recent studies in mice proposing that leptin may be mediating this effect. This regulation, however, may not extend to humans, where a yet-to-be-identified factor is likely the underlying cause of hypertension.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26232214      PMCID： PMC7262432          DOI： 10.1016/j.cell.2015.07.007

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  4 in total

1.  Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial.

Authors:  S B Heymsfield; A S Greenberg; K Fujioka; R M Dixon; R Kushner; T Hunt; J A Lubina; J Patane; B Self; P Hunt; M McCamish
Journal:  JAMA       Date:  1999-10-27       Impact factor: 56.272

2.  Leptin-replacement therapy for lipodystrophy.

Authors:  Elif Arioglu Oral; Vinaya Simha; Elaine Ruiz; Alexa Andewelt; Ahalya Premkumar; Peter Snell; Anthony J Wagner; Alex M DePaoli; Marc L Reitman; Simeon I Taylor; Phillip Gorden; Abhimanyu Garg
Journal:  N Engl J Med       Date:  2002-02-21       Impact factor: 91.245

3.  Leptin mediates the increase in blood pressure associated with obesity.

Authors:  Stephanie E Simonds; Jack T Pryor; Eric Ravussin; Frank L Greenway; Ralph Dileone; Andrew M Allen; Jaspreet Bassi; Joel K Elmquist; Julia M Keogh; Elana Henning; Martin G Myers; Julio Licinio; Russell D Brown; Pablo J Enriori; Stephen O'Rahilly; Scott M Sternson; Kevin L Grove; David C Spanswick; I Sadaf Farooqi; Michael A Cowley
Journal:  Cell       Date:  2014-12-04       Impact factor: 41.582

4.  Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

Authors:  I Sadaf Farooqi; Giuseppe Matarese; Graham M Lord; Julia M Keogh; Elizabeth Lawrence; Chizo Agwu; Veronica Sanna; Susan A Jebb; Francesco Perna; Silvia Fontana; Robert I Lechler; Alex M DePaoli; Stephen O'Rahilly
Journal:  J Clin Invest       Date:  2002-10       Impact factor: 14.808
  4 in total
  17 in total

Review 1.  Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication.

Authors:  Jan-Bernd Funcke; Philipp E Scherer
Journal:  J Lipid Res       Date:  2019-06-17       Impact factor: 5.922

Review 2.  Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.

Authors:  Cristina Adelia Meehan; Elaine Cochran; Andrea Kassai; Rebecca J Brown; Phillip Gorden
Journal:  Expert Rev Clin Pharmacol       Date:  2015-10-14       Impact factor: 5.045

3.  Impact of leptin deficiency compared with neuronal-specific leptin receptor deletion on cardiometabolic regulation.

Authors:  Jussara M do Carmo; Alexandre A da Silva; Fabio N Gava; Sydney P Moak; Xuemei Dai; John E Hall
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2019-08-14       Impact factor: 3.619

4.  Identification of Leptin Receptor-Expressing Cells in the Nodose Ganglion of Male Mice.

Authors:  Luis Leon Mercado; Alexandre Caron; Yibing Wang; Michael Burton; Laurent Gautron
Journal:  Endocrinology       Date:  2019-05-01       Impact factor: 4.736

5.  Adiponectin protects against incident hypertension independent of body fat distribution: observations from the Dallas Heart Study.

Authors:  Poghni A Peri-Okonny; Colby Ayers; Naim Maalouf; Sandeep R Das; James A de Lemos; Jarett D Berry; Aslan T Turer; Ian J Neeland; Philipp E Scherer; Wanpen Vongpatanasin
Journal:  Diabetes Metab Res Rev       Date:  2016-08-18       Impact factor: 4.876

6.  Hypertension and Diabetes Mellitus: Coprediction and Time Trajectories.

Authors:  Vasilis Tsimihodimos; Clicerio Gonzalez-Villalpando; James B Meigs; Ele Ferrannini
Journal:  Hypertension       Date:  2018-01-15       Impact factor: 10.190

7.  Central Leptin and Tumor Necrosis Factor-α (TNFα) in Diurnal Control of Blood Pressure and Hypertension.

Authors:  Cheng Han; Wenhe Wu; Albert Ale; Min Soo Kim; Dongsheng Cai
Journal:  J Biol Chem       Date:  2016-05-13       Impact factor: 5.157

Review 8.  Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology.

Authors:  Makoto Ishii; Costantino Iadecola
Journal:  Biochim Biophys Acta       Date:  2015-11-09

Review 9.  Leptin in Leanness and Obesity: JACC State-of-the-Art Review.

Authors:  Nikolaos Perakakis; Olivia M Farr; Christos S Mantzoros
Journal:  J Am Coll Cardiol       Date:  2021-02-16       Impact factor: 24.094

10.  Leptin Is Not Essential for Obesity-Associated Hypertension.

Authors:  Julia von Schnurbein; Jaida Manzoor; Stephanie Brandt; Friederike Denzer; Katja Kohlsdorf; Pamela Fischer-Posovszky; Mario Weißenberger; Sabine Frank-Podlech; Saqib Mahmood; Martin Wabitsch
Journal:  Obes Facts       Date:  2019-07-29       Impact factor: 3.942
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