Gang Chen1, Youfa Zhou1, Qingyu Shi2, Haiyan Zhou3. 1. Department of Anaesthesia, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. 2. Department of Anaesthesia, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. 3. Department of Anaesthesia, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China doctor_haiyanzhou@163.com.
Abstract
OBJECTIVES: A meta-analysis to compare postoperative cognitive function and the time to specific recovery events in elderly patients (aged >65 years) anaesthetized with sevoflurane or desflurane. METHODS: A systematic search of the PubMed(®), Embase(®), Cochrane Library and Chinese Biomedical databases was performed using the keywords 'sevoflurane' and 'desflurane'. Data and characteristics of appropriate randomized controlled trials (RCTs) were extracted. RESULTS: The meta-analysis included five trials (n = 300). The time taken to follow commands (mean difference [MD] -3.27; 95% confidence intervals [CI] -4.95, -1.59), extubation (MD -1.59; 95%CI -2.62, -0.55), orientation (MD -4.31; 95%CI -4.99, -3.62), and recovery room discharge (MD -9.38; 95%CI -13.43, -5.42) were significantly shorter in the desflurane group than in the sevoflurane group. There was no significant between-drug difference in the incidence of postoperative cognitive dysfunction or the time taken to open the eyes. CONCLUSIONS: Desflurane is associated with a faster recovery from general anaesthesia than sevoflurane in elderly patients.
OBJECTIVES: A meta-analysis to compare postoperative cognitive function and the time to specific recovery events in elderly patients (aged >65 years) anaesthetized with sevoflurane or desflurane. METHODS: A systematic search of the PubMed(®), Embase(®), Cochrane Library and Chinese Biomedical databases was performed using the keywords 'sevoflurane' and 'desflurane'. Data and characteristics of appropriate randomized controlled trials (RCTs) were extracted. RESULTS: The meta-analysis included five trials (n = 300). The time taken to follow commands (mean difference [MD] -3.27; 95% confidence intervals [CI] -4.95, -1.59), extubation (MD -1.59; 95%CI -2.62, -0.55), orientation (MD -4.31; 95%CI -4.99, -3.62), and recovery room discharge (MD -9.38; 95%CI -13.43, -5.42) were significantly shorter in the desflurane group than in the sevoflurane group. There was no significant between-drug difference in the incidence of postoperative cognitive dysfunction or the time taken to open the eyes. CONCLUSIONS:Desflurane is associated with a faster recovery from general anaesthesia than sevoflurane in elderly patients.
Authors: Omar A Ababneh; Aiman M Suleiman; Isam K Bsisu; Subhi M Al-Ghanem; Walid K Samarah; Khaled R Al-Zaben; Ibraheem Y Qudaisat; Lubna A Khreesha; Ghazi M Al Edwan; Mujalli M Murshidi Journal: Medicina (Kaunas) Date: 2020-12-10 Impact factor: 2.430