BACKGROUND: The prognostic value of poststent fractional flow reserve (FFR) has not been clearly defined in patients with drug-eluting stent (DES) implantation. This study sought to evaluate the association between FFR and clinical outcomes after DES implantation with intravascular ultrasound (IVUS) assistance. METHODS: A total of 115 lesions (107 patients) with FFR measurement after IVUS-assisted DES implantation were enrolled. Poststent angiographic and IVUS parameters were compared with FFR values. Clinical outcomes were assessed by target vessel failure (TVF), defined as a composite of target vessel revascularization, death, or non-fatal myocardial infarction attributed to the target vessel. RESULTS: Mean poststent FFR was 0.92 ± 0.04. Minimal stent area by IVUS had a positive correlation with poststent FFR (r = 0.36; P<.01). Poststent FFR ≥0.89 was a physiologic cut-off value for 1-year TVF-free survival. The best cut-off value of minimal stent area to define poststent FFR ≥0.89 was >5.4 mm² (sensitivity, 63.2%; specificity, 90.0%). At 3-year follow-up, lesions with poststent FFR ≥0.89 had a better TVF-free survival rate than those with poststent FFR <0.89 (89.3% vs 61.1%, P =.03). CONCLUSION: Poststent FFR can be a useful predictor for long-term clinical outcomes after DES implantation and relevant to IVUS minimal stent area.
BACKGROUND: The prognostic value of poststent fractional flow reserve (FFR) has not been clearly defined in patients with drug-eluting stent (DES) implantation. This study sought to evaluate the association between FFR and clinical outcomes after DES implantation with intravascular ultrasound (IVUS) assistance. METHODS: A total of 115 lesions (107 patients) with FFR measurement after IVUS-assisted DES implantation were enrolled. Poststent angiographic and IVUS parameters were compared with FFR values. Clinical outcomes were assessed by target vessel failure (TVF), defined as a composite of target vessel revascularization, death, or non-fatal myocardial infarction attributed to the target vessel. RESULTS: Mean poststent FFR was 0.92 ± 0.04. Minimal stent area by IVUS had a positive correlation with poststent FFR (r = 0.36; P<.01). Poststent FFR ≥0.89 was a physiologic cut-off value for 1-year TVF-free survival. The best cut-off value of minimal stent area to define poststent FFR ≥0.89 was >5.4 mm² (sensitivity, 63.2%; specificity, 90.0%). At 3-year follow-up, lesions with poststent FFR ≥0.89 had a better TVF-free survival rate than those with poststent FFR <0.89 (89.3% vs 61.1%, P =.03). CONCLUSION: Poststent FFR can be a useful predictor for long-term clinical outcomes after DES implantation and relevant to IVUS minimal stent area.
Authors: Mathias Wolfrum; Gregor Fahrni; Giovanni Luigi de Maria; Guido Knapp; Nick Curzen; Rajesh K Kharbanda; Georg M Fröhlich; Adrian P Banning Journal: BMC Cardiovasc Disord Date: 2016-09-08 Impact factor: 2.298
Authors: Doyeon Hwang; Bon-Kwon Koo; Jinlong Zhang; Jiesuck Park; Seokhun Yang; Minsang Kim; Jun Pil Yun; Joo Myung Lee; Chang-Wook Nam; Eun-Seok Shin; Joon-Hyung Doh; Shao-Liang Chen; Tsunekazu Kakuta; Gabor G Toth; Zsolt Piroth; Nils P Johnson; Nico H J Pijls; Abdul Hakeem; Barry F Uretsky; Yohei Hokama; Nobuhiro Tanaka; Hong-Seok Lim; Tsuyoshi Ito; Akiko Matsuo; Lorenzo Azzalini; Massoud A Leesar; Tara Neleman; Nicolas M van Mieghem; Roberto Diletti; Joost Daemen; Damien Collison; Carlos Collet; Bernard De Bruyne Journal: JAMA Netw Open Date: 2022-09-01
Authors: Damien Collison; Matthaios Didagelos; Muhammad Aetesam-Ur-Rahman; Samuel Copt; Robert McDade; Peter McCartney; Thomas J Ford; John McClure; Mitchell Lindsay; Aadil Shaukat; Paul Rocchiccioli; Richard Brogan; Stuart Watkins; Margaret McEntegart; Richard Good; Keith Robertson; Patrick O'Boyle; Andrew Davie; Adnan Khan; Stuart Hood; Hany Eteiba; Colin Berry; Keith G Oldroyd Journal: Eur Heart J Date: 2021-12-01 Impact factor: 29.983