Literature DB >> 26231733

Cell death decision by p53 via control of the mitochondrial membrane.

Nurmaa Dashzeveg1, Kiyotsugu Yoshida2.   

Abstract

The tumor suppressor p53 is mutated in more than half of human cancers. Recent evidence has revealed that p53 not only regulates apoptosis but also regulates necrotic/necroptotic cell death via the mitochondria. The regulation of apoptosis by p53 is tightly connected to the mitochondrial outer membrane permeabilization and the induction of and interaction with Bcl-2 family members. Interestingly, p53-mediated regulation of necrosis/necroptosis is correlated with mitochondrial permeabilization pore opening via interactions with CypD and Drp1. This review discusses the p53-regulating molecules that induce apoptosis or necrosis/necroptosis via the mitochondria.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Apoptosis; Mitochondria; Necroptosis; Necrosis; p53

Mesh：

Substances：

Year:  2015        PMID： 26231733     DOI： 10.1016/j.canlet.2015.07.019

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  30 in total

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Authors:  Rafaela Muniz de Queiroz; Rashna Madan; Jeremy Chien; Wagner Barbosa Dias; Chad Slawson
Journal:  J Biol Chem       Date:  2016-07-11       Impact factor: 5.157

2.  Activation of death receptor, DR5 and mitochondria-mediated apoptosis by a 3,4,5-trimethoxybenzyloxy derivative in wild-type and p53 mutant colorectal cancer cell lines.

Authors:  Zachariah Chee Ken Chan; Kok Hoong Leong; Huda Salah Kareem; Anwar Norazit; Suzita Mohd Noor; Azhar Ariffin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2019-10-23       Impact factor: 3.000

3.  Dynamin-Related Protein 1 Deficiency Leads to Receptor-Interacting Protein Kinase 3-Mediated Necroptotic Neurodegeneration.

Authors:  Tatsuya Yamada; Yoshihiro Adachi; Masahiro Fukaya; Miho Iijima; Hiromi Sesaki
Journal:  Am J Pathol       Date:  2016-09-15       Impact factor: 4.307

4.  Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis.

Authors:  Yonghua Zhuang; Heather M Berens-Norman; J Smith Leser; Penny Clarke; Kenneth L Tyler
Journal:  J Virol       Date:  2016-08-12       Impact factor: 5.103

5.  Establishment of a Cell Necroptosis Index to Predict Prognosis and Drug Sensitivity for Patients With Triple-Negative Breast Cancer.

Authors:  Jindong Xie; Wenwen Tian; Yuhui Tang; Yutian Zou; Shaoquan Zheng; Linyu Wu; Yan Zeng; Song Wu; Xinhua Xie; Xiaoming Xie
Journal:  Front Mol Biosci       Date:  2022-05-05

6.  Pteisolic acid G, a novel ent-kaurane diterpenoid, inhibits viability and induces apoptosis in human colorectal carcinoma cells.

Authors:  Shuangli Qiu; Xin Wu; Hongbo Liao; Xiaobin Zeng; Senwang Zhang; Xiaofen Lu; Xiaohong He; Xiaoqi Zhang; Wencai Ye; Hua Wu; Xiaohui Zhu
Journal:  Oncol Lett       Date:  2017-09-06       Impact factor: 2.967

7.  Bovine herpesviruses induce different cell death forms in neuronal and glial-derived tumor cell cultures.

Authors:  Tereza C Cardoso; Ana Carolina G Rosa; Helena L Ferreira; Lucas H Okamura; Bruna R S M Oliveira; Flavia V Vieira; Camila Silva-Frade; Roberto Gameiro; Eduardo F Flores
Journal:  J Neurovirol       Date:  2016-06-16       Impact factor: 2.643

Review 8.  The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death.

Authors:  Evgeniia A Prokhorova; Aleksandra Yu Egorshina; Boris Zhivotovsky; Gelina S Kopeina
Journal:  Oncogene       Date:  2019-08-28       Impact factor: 9.867

9.  Climacostol reduces tumour progression in a mouse model of melanoma via the p53-dependent intrinsic apoptotic programme.

Authors:  Cristiana Perrotta; Federico Buonanno; Silvia Zecchini; Alessio Giavazzi; Francesca Proietti Serafini; Elisabetta Catalani; Laura Guerra; Maria Cristina Belardinelli; Simona Picchietti; Anna Maria Fausto; Simone Giorgi; Enrico Marcantoni; Emilio Clementi; Claudio Ortenzi; Davide Cervia
Journal:  Sci Rep       Date:  2016-06-07       Impact factor: 4.379

10.  Exposure of the cytoplasm to low-dose X-rays modifies ataxia telangiectasia mutated-mediated DNA damage responses.

Authors:  Munetoshi Maeda; Masanori Tomita; Mika Maeda; Hideki Matsumoto; Noriko Usami; Kyo Kume; Katsumi Kobayashi
Journal:  Sci Rep       Date:  2021-07-05       Impact factor: 4.379
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