R Y Yang1, S M Wang1, L Sun1, J M Liu2, H X Li1, X F Sui3, M Wang4, H L Xiu1, S Wang1, Q He2, J Dong5, W X Chen4. 1. The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China. 2. Department of Cardiology, Beijing Hospital, Ministry of Health, Beijing, China. 3. The First Affiliated Hospital, Jiamusi University, Heilongjiang, China. 4. The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China; Beijing Hospital, National Center for Clinical Laboratories, Ministry of Health, Beijing, China. 5. The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China. Electronic address: jun_dong@263.net.
Abstract
BACKGROUND AND AIM: Several recent studies have found an independent relationship between levels of plasma branched-chain amino acids (BCAAs) and risk factors for coronary artery disease (CAD); however, few studies have investigated the associations of BCAAs with CAD and the risk of cardiovascular events. Therefore, the aim of this study was to investigate the relationship between BCAAs and CAD. METHODS AND RESULTS: We studied 143 patients with CAD diagnosed by coronary angiography at Beijing Hospital (Beijing, China) during 2008-2011. Apparently healthy control individuals (n = 286) and the patients with CAD were matched (2:1 ratio) by age and gender. The healthy control individuals were selected at random from a set of subjects who attended an annual physical examination at the same hospital in 2011. Conditional logistic regression models were used to evaluate the associations between measured variables and CAD. After multivariate adjustment for traditional CAD risk factors, each one-standard-deviation increase in BCAA concentration was associated with an approximately twofold increase in the risk of CAD (odds ratio = 1.63, 95% confidence interval (CI): 1.21-2.20, P = 0.001). As compared with subjects in the lowest quartile of BCAA levels, the odds ratios (95% CIs) for CAD risk in subjects belonging to quartiles 2, 3, and 4 were 1.65 (0.75-3.61), 2.04 (0.92-4.53), and 3.86 (1.71-8.69), respectively (P trend = 0.01). CONCLUSION: Our results demonstrate that BCAAs are significantly related to CAD development. This relationship is independent of diabetes, hypertension, dyslipidemia, and body mass index.
BACKGROUND AND AIM: Several recent studies have found an independent relationship between levels of plasma branched-chain amino acids (BCAAs) and risk factors for coronary artery disease (CAD); however, few studies have investigated the associations of BCAAs with CAD and the risk of cardiovascular events. Therefore, the aim of this study was to investigate the relationship between BCAAs and CAD. METHODS AND RESULTS: We studied 143 patients with CAD diagnosed by coronary angiography at Beijing Hospital (Beijing, China) during 2008-2011. Apparently healthy control individuals (n = 286) and the patients with CAD were matched (2:1 ratio) by age and gender. The healthy control individuals were selected at random from a set of subjects who attended an annual physical examination at the same hospital in 2011. Conditional logistic regression models were used to evaluate the associations between measured variables and CAD. After multivariate adjustment for traditional CAD risk factors, each one-standard-deviation increase in BCAA concentration was associated with an approximately twofold increase in the risk of CAD (odds ratio = 1.63, 95% confidence interval (CI): 1.21-2.20, P = 0.001). As compared with subjects in the lowest quartile of BCAA levels, the odds ratios (95% CIs) for CAD risk in subjects belonging to quartiles 2, 3, and 4 were 1.65 (0.75-3.61), 2.04 (0.92-4.53), and 3.86 (1.71-8.69), respectively (P trend = 0.01). CONCLUSION: Our results demonstrate that BCAAs are significantly related to CAD development. This relationship is independent of diabetes, hypertension, dyslipidemia, and body mass index.
Authors: Barbara N DeRatt; Maria A Ralat; Vegard Lysne; Fariba Tayyari; Indu Dhar; Arthur S Edison; Timothy J Garrett; Øivind Midttun; Per Magne Ueland; Ottar Kjell Nygård; Jesse F Gregory Journal: J Nutr Date: 2017-08-09 Impact factor: 4.798
Authors: Olha Zhenyukh; Maria González-Amor; Raul R Rodrigues-Diez; Vanesa Esteban; Marta Ruiz-Ortega; Mercedes Salaices; Sebastian Mas; Ana M Briones; Jesus Egido Journal: J Cell Mol Med Date: 2018-07-31 Impact factor: 5.310