Amy Y Zhang1, Donald R Bodner2, Alex Z Fu3, Douglas D Gunzler4, Eric Klein5, Denise Kresevic6, Shirley Moore7, Lee Ponsky8, Michael Purdum6, Gerald Strauss6, Hui Zhu9. 1. School of Nursing, Case Western Reserve University, Cleveland, Ohio. Electronic address: Amy.Zhang@case.edu. 2. Department of Urology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio; School of Medicine, Case Western Reserve University, Cleveland, Ohio; Urology Clinic, Cleveland, Ohio. 3. Cancer Prevention and Control Program, Georgetown University Medical Center, Washington, D.C. 4. Center for Health Care Research and Policy, Case Western Reserve University, Cleveland, Ohio. 5. Glickman Urological and Kidney Institute, Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio. 6. Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio. 7. School of Nursing, Case Western Reserve University, Cleveland, Ohio. 8. Department of Urology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio. 9. School of Medicine, Case Western Reserve University, Cleveland, Ohio; Urology Clinic, Cleveland, Ohio.
Abstract
PURPOSE: We examined whether an intervention combining pelvic floor muscle exercise and symptom self-management would improve urinary continence and quality of life in patients with prostate cancer. MATERIALS AND METHODS: In a randomized, controlled, longitudinal clinical trial 279 patients with prostate cancer with persistent urinary incontinence were randomized to 1 of 3 groups, including biofeedback pelvic floor muscle exercise plus a support group, the biofeedback exercise plus telephone contact and usual care without intervention. The biofeedback plus support and plus telephone groups received 1 session of biofeedback assisted exercise and 6 biweekly sessions of problem solving therapy. This delivered symptom management skills through a peer support group or telephone contacts for 3 months. All subjects were assessed in blinded fashion at baseline, and 3 and 6 months for urinary leakage frequency, leakage amount and disease specific quality of life. RESULTS: A total of 244 subjects completed the study. The biofeedback plus support and biofeedback plus telephone groups had a lower frequency of daily urinary leakage than the group with usual care without intervention at 3 months (p=0.019 and p≤0.001, respectively) but not at 6 months. The biofeedback plus support group but not the biofeedback plus telephone group had 13.3 gm lower leakage at 6 months than the usual care group (p=0.003). Overall the biofeedback plus support and plus telephone groups reported less symptom severity (p≤0.001) and fewer incontinence problems (p≤0.01) than the usual care group at 6 months. CONCLUSIONS: Study findings show that pelvic floor muscle exercise practice plus symptom self-management in a peer support setting can significantly improve urinary continence and quality of life in patients with prostate cancer.
RCT Entities:
PURPOSE: We examined whether an intervention combining pelvic floor muscle exercise and symptom self-management would improve urinary continence and quality of life in patients with prostate cancer. MATERIALS AND METHODS: In a randomized, controlled, longitudinal clinical trial 279 patients with prostate cancer with persistent urinary incontinence were randomized to 1 of 3 groups, including biofeedback pelvic floor muscle exercise plus a support group, the biofeedback exercise plus telephone contact and usual care without intervention. The biofeedback plus support and plus telephone groups received 1 session of biofeedback assisted exercise and 6 biweekly sessions of problem solving therapy. This delivered symptom management skills through a peer support group or telephone contacts for 3 months. All subjects were assessed in blinded fashion at baseline, and 3 and 6 months for urinary leakage frequency, leakage amount and disease specific quality of life. RESULTS: A total of 244 subjects completed the study. The biofeedback plus support and biofeedback plus telephone groups had a lower frequency of daily urinary leakage than the group with usual care without intervention at 3 months (p=0.019 and p≤0.001, respectively) but not at 6 months. The biofeedback plus support group but not the biofeedback plus telephone group had 13.3 gm lower leakage at 6 months than the usual care group (p=0.003). Overall the biofeedback plus support and plus telephone groups reported less symptom severity (p≤0.001) and fewer incontinence problems (p≤0.01) than the usual care group at 6 months. CONCLUSIONS: Study findings show that pelvic floor muscle exercise practice plus symptom self-management in a peer support setting can significantly improve urinary continence and quality of life in patients with prostate cancer.
Authors: Amy Y Zhang; Stephen Ganocy; Alex Z Fu; Denise Kresevic; Lee Ponsky; Gerald Strauss; Donald R Bodner; Hui Zhu Journal: Support Care Cancer Date: 2019-03-22 Impact factor: 3.603
Authors: Amy Y Zhang; Alex Z Fu; Shirley Moore; Hui Zhu; Gerald Strauss; Denise Kresevic; Eric Klein; Lee Ponsky; Donald R Bodner Journal: J Cancer Surviv Date: 2016-06-24 Impact factor: 4.442
Authors: Philipp Zimmer; Freerk T Baumann; Max Oberste; Peter Wright; Alexander Garthe; Alexander Schenk; Thomas Elter; Daniel A Galvao; Wilhelm Bloch; Sven T Hübner; Florian Wolf Journal: Biomed Res Int Date: 2016-04-10 Impact factor: 3.411