Vanessa Perez1, Kristina D Mena2, Heather N Watson3, R Burt Prater4, John L McIntyre5. 1. Center for Epidemiology, Biostatistics, and Computational Biology, Exponent Health Sciences, Chicago, Ill. 2. Department is Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center, School of Public Health, Houston, TX. 3. Statistical and Data Sciences Practice, Exponent, Menlo Park, CA. 4. HealthCure, LLC, Detroit, MI. 5. HealthCure, LLC, Detroit, MI. Electronic address: jlmci@aol.com.
Abstract
BACKGROUND: It is generally agreed that contaminated hospital surfaces play a role in the transmission of hospital-acquired infections (HAIs). The ability of an antimicrobial agent, engineered at Emory University, to reduce bacterial bioburden on hospital surfaces was examined. A quantitative microbial risk assessment was also conducted to quantify the potential reduction of human health risks associated with application of this antimicrobial product. METHODS: A 1-arm, prospective observational study was conducted. High-frequency contact surfaces within 18 hospital patient rooms were sampled in between patient use. Negative binomial regression with repeated measures was used to examine log CFU/100 cm(2) reductions in total, gram-negative, and Staphylococcus aureus microorganisms. Standard risk assessment methods were used. RESULTS: Multivariate regression demonstrated significant reductions in gram-negative (P < .0001) and S aureus (P = .009) bacteria with increasing patient turnover. No reduction was observed in total bacteria (P = .93). Infection risks were reduced by 4 and 3 logs for gram-positive and gram-negative bacteria, respectively. These risk reductions, along with HAI survey studies, suggest that application of this antimicrobial product could prevent as many as 5%-10% of HAIs. CONCLUSIONS: This study was the first evaluation of a distinctive antimicrobial agent for hospital surface treatment. The findings provide support for the utility of an antimicrobial product in potentially reducing HAI transmission from contaminated environment surfaces.
BACKGROUND: It is generally agreed that contaminated hospital surfaces play a role in the transmission of hospital-acquired infections (HAIs). The ability of an antimicrobial agent, engineered at Emory University, to reduce bacterial bioburden on hospital surfaces was examined. A quantitative microbial risk assessment was also conducted to quantify the potential reduction of human health risks associated with application of this antimicrobial product. METHODS: A 1-arm, prospective observational study was conducted. High-frequency contact surfaces within 18 hospital patient rooms were sampled in between patient use. Negative binomial regression with repeated measures was used to examine log CFU/100 cm(2) reductions in total, gram-negative, and Staphylococcus aureus microorganisms. Standard risk assessment methods were used. RESULTS: Multivariate regression demonstrated significant reductions in gram-negative (P < .0001) and S aureus (P = .009) bacteria with increasing patient turnover. No reduction was observed in total bacteria (P = .93). Infection risks were reduced by 4 and 3 logs for gram-positive and gram-negative bacteria, respectively. These risk reductions, along with HAI survey studies, suggest that application of this antimicrobial product could prevent as many as 5%-10% of HAIs. CONCLUSIONS: This study was the first evaluation of a distinctive antimicrobial agent for hospital surface treatment. The findings provide support for the utility of an antimicrobial product in potentially reducing HAI transmission from contaminated environment surfaces.
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