Literature DB >> 26230879

The promise of zebrafish as a chemical screening tool in cancer therapy.

Xiayang Xie1, James L Ross2, John K Cowell1, Yong Teng1,3.   

Abstract

Cancer progression in zebrafish recapitulates many aspects of human cancer and as a result, zebrafish have been gaining popularity for their potential use in basic and translational cancer research. Human cancer can be modeled in zebrafish by induction using chemical mutagens, xenotransplantation or by genetic manipulation. Chemical screens based on zebrafish cancer models offer a rapid, powerful and inexpensive means of evaluating the potential of suppression or prevention on cancer. The identification of small molecules through such screens will serve as ideal entry points for novel chemical therapies for cancer treatment. This article outlines advances that have been made within the growing field of zebrafish cancer models and presents their advantages for chemical drug screening.

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Mesh：

Year:  2015        PMID： 26230879     DOI： 10.4155/fmc.15.73

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


  11 in total

1.  Delivery of Small Interfering RNA to Inhibit Vascular Endothelial Growth Factor in Zebrafish Using Natural Brain Endothelia Cell-Secreted Exosome Nanovesicles for the Treatment of Brain Cancer.

Authors:  Tianzhi Yang; Brittany Fogarty; Bret LaForge; Salma Aziz; Thuy Pham; Leanne Lai; Shuhua Bai
Journal:  AAPS J       Date:  2016-11-23       Impact factor: 4.009

2.  Zebrafish Embryo Xenograft and Metastasis Assay.

Authors:  Ilkka Paatero; Sanni Alve; Silvia Gramolelli; Johanna Ivaska; Päivi M Ojala
Journal:  Bio Protoc       Date:  2018-09-20

3.  Activity of gallic acid and its ester derivatives in Caenorhabditis elegans and zebrafish (Danio rerio) models.

Authors:  Junya de Lacorte Singulani; Liliana Scorzoni; Paulo César Gomes; Ana Carolina Nazaré; Carlos Roberto Polaquini; Luis Octávio Regasini; Ana Marisa Fusco-Almeida; Maria José Soares Mendes-Giannini
Journal:  Future Med Chem       Date:  2017-10-27       Impact factor: 3.808

Review 4.  The Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines.

Authors:  C Gutiérrez-Lovera; A J Vázquez-Ríos; J Guerra-Varela; L Sánchez; M de la Fuente
Journal:  Genes (Basel)       Date:  2017-11-28       Impact factor: 4.096

Review 5.  The MeLiM Minipig: An Original Spontaneous Model to Explore Cutaneous Melanoma Genetic Basis.

Authors:  Emmanuelle Bourneuf
Journal:  Front Genet       Date:  2017-10-13       Impact factor: 4.599

Review 6.  Unveiling Tumor Microenvironment Interactions Using Zebrafish Models.

Authors:  Reid Loveless; Chloe Shay; Yong Teng
Journal:  Front Mol Biosci       Date:  2021-01-14

7.  Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1.

Authors:  Xiayang Xie; Shou-Ching Tang; Yafei Cai; Wenhu Pi; Libin Deng; Guangyu Wu; Alain Chavanieu; Yong Teng
Journal:  Oncotarget       Date:  2016-09-06

8.  Dual targeting of the cancer antioxidant network with 1,4-naphthoquinone fused Gold(i) N-heterocyclic carbene complexes.

Authors:  R McCall; M Miles; P Lascuna; B Burney; Z Patel; K J Sidoran; V Sittaramane; J Kocerha; D A Grossie; J L Sessler; K Arumugam; J F Arambula
Journal:  Chem Sci       Date:  2017-07-21       Impact factor: 9.825

Review 9.  Modeling the developmental origins of pediatric cancer to improve patient outcomes.

Authors:  James F Amatruda
Journal:  Dis Model Mech       Date:  2021-02-22       Impact factor: 5.732

Review 10.  Zebrafish as a Model for Anticancer Nanomedicine Studies.

Authors:  Hissa F Al-Thani; Samar Shurbaji; Huseyin C Yalcin
Journal:  Pharmaceuticals (Basel)       Date:  2021-06-28
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