Yuichiro Nishida1, Keitaro Tanaka2, Megumi Hara2, Noriko Hirao3, Hiroaki Tanaka3, Takuro Tobina4, Masaharu Ikeda5, Hiroshi Yamato6, Masanori Ohta6. 1. Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan. Electronic address: ynishida@cc.saga-u.ac.jp. 2. Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan. 3. Laboratory of Exercise Physiology, Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan. 4. Faculty of Nursing and Nutrition, University of Nagasaki, Nagasaki, Japan. 5. Fukuseikai Minami Hospital, Fukuoka, Japan. 6. Department of Health Development, Institute of Industrial Ecological Science, University of Occupational and Environmental Health, Kitakyushu, Japan.
Abstract
PURPOSE: The purpose of the current study was to investigate the effects of a 12-week home-based bench step exercise program on inflammatory cytokines and lipid profiles in elderly females. METHODS:Sixty-two postmenopausal females (65-85 years of age) were randomized to either the bench step exercise group (n=31) or the control group (n=31). The subjects in the bench step exercise group were instructed to perform bench step exercises at the exercise intensity corresponding to lactate threshold (LT), three times per day 10-20 min each session, for a goal of ≥140 min/week at home for 12 weeks. At baseline and 12 weeks, circulating levels of nine inflammatory cytokines (high-molecular-weight adiponectin, interleukin-4 [IL-4], IL-5, IL-6, IL-8, IL-15, tumor necrosis factor-α [TNF-α], TNF-β and interferon-γ [IFN-γ]) and serum lipids including high-density lipoprotein cholesterol (HDL-C) were measured. RESULTS: The bench step training at the LT significantly increased HDL-C levels and decreased IFN-γ concentrations in the subjects with lower (< 63 mg/dL) baseline HDL-C levels (p<0.05). The change in IFN-γ inversely correlated with the change in HDL-C in the exercise group (ρ=-0.56, p<0.01), whereas this association was not observed in the control group. Additionally, principal component analysis-derived index of what we called "inflammatory status factor" was inversely associated with the changes in HDL-C in the exercise group. CONCLUSION: The bench step exercise-induced reduction in the IFN-γ levels may partially explain the degree of improvement in the HDL-C levels with the exercise program.
RCT Entities:
PURPOSE: The purpose of the current study was to investigate the effects of a 12-week home-based bench step exercise program on inflammatory cytokines and lipid profiles in elderly females. METHODS: Sixty-two postmenopausal females (65-85 years of age) were randomized to either the bench step exercise group (n=31) or the control group (n=31). The subjects in the bench step exercise group were instructed to perform bench step exercises at the exercise intensity corresponding to lactate threshold (LT), three times per day 10-20 min each session, for a goal of ≥140 min/week at home for 12 weeks. At baseline and 12 weeks, circulating levels of nine inflammatory cytokines (high-molecular-weight adiponectin, interleukin-4 [IL-4], IL-5, IL-6, IL-8, IL-15, tumor necrosis factor-α [TNF-α], TNF-β and interferon-γ [IFN-γ]) and serum lipids including high-density lipoprotein cholesterol (HDL-C) were measured. RESULTS: The bench step training at the LT significantly increased HDL-C levels and decreased IFN-γ concentrations in the subjects with lower (< 63 mg/dL) baseline HDL-C levels (p<0.05). The change in IFN-γ inversely correlated with the change in HDL-C in the exercise group (ρ=-0.56, p<0.01), whereas this association was not observed in the control group. Additionally, principal component analysis-derived index of what we called "inflammatory status factor" was inversely associated with the changes in HDL-C in the exercise group. CONCLUSION: The bench step exercise-induced reduction in the IFN-γ levels may partially explain the degree of improvement in the HDL-C levels with the exercise program.
Authors: Matheus U Chupel; Fábio Direito; Guilherme E Furtado; Luciéle G Minuzzi; Filipa M Pedrosa; Juan C Colado; José P Ferreira; Edith Filaire; Ana M Teixeira Journal: Front Physiol Date: 2017-06-12 Impact factor: 4.566
Authors: Remigiusz Domin; Daniela Dadej; Michał Pytka; Ariadna Zybek-Kocik; Marek Ruchała; Przemysław Guzik Journal: Int J Environ Res Public Health Date: 2021-01-31 Impact factor: 3.390