| Literature DB >> 26228648 |
Wenpei Fan1, Wenbo Bu2, Zhen Zhang3, Bo Shen4, Hui Zhang3, Qianjun He1, Dalong Ni1, Zhaowen Cui1, Kuaile Zhao3, Jiwen Bu5, Jiulin Du5, Jianan Liu1, Jianlin Shi6.
Abstract
Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs in vitro and in vivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.Entities:
Keywords: NO release; X-ray radiation; hypoxic radiosensitization; luminescent imaging; on-demand therapy
Mesh：
Substances：
Year: 2015 PMID： 26228648 DOI： 10.1002/anie.201504536
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336