Sila Genc1,2,3, Christopher E Steward1,2, Charles B Malpas2,4, Dennis Velakoulis2,5, Terence J O'Brien2,6, Patricia M Desmond1,7. 1. Department of Radiology, The University of Melbourne, Melbourne, Australia. 2. Melbourne Brain Centre, Royal Melbourne Hospital, Melbourne, Australia. 3. Murdoch Children's Research Institute, Melbourne, Australia. 4. Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Australia. 5. Melbourne Neuropsychiatry Centre, Royal Melbourne Hospital, Melbourne, Australia. 6. Department of Medicine, The University of Melbourne, Melbourne, Australia. 7. Department of Radiology, Royal Melbourne Hospital, Melbourne, Australia.
Abstract
PURPOSE: To investigate whether there are any white matter changes in a 6-month follow-up of mild-moderate Alzheimer's patients using diffusion tensor imaging (DTI). MATERIALS AND METHODS: We recruited 18 mild-moderate Alzheimer's disease patients and they underwent magnetic resonance imaging (MRI) at recruitment and at 6-month follow-up. Diffusion MRI images were processed using DTI-ToolKit to create a population-based tensor template. This template was integrated with a voxel-wise and atlas-based analysis in FSL to determine the magnitude and location of change in diffusion metrics over the 6-month follow-up period. RESULTS: There were significant widespread changes in diffusion metrics across the entire white matter skeleton (P < 0.001), 95% confidence interval (CI) difference in fractional anisotropy: -0.007 (-0.011, -0.002), mean diffusivity: 0.040 (0.023, 0.058), axial diffusivity: 0.015 (0.008, 0.022), radial diffusivity: 0.012 (0.006, 0.019), as well as regions of interest in the splenium and superior longitudinal fasciculus. CONCLUSION: Our findings show that diffusion metrics are altered in a 6-month follow-up period of mild-moderate Alzheimer's patients, supporting the potential of DTI metrics to act as sensitive biomarkers for disease progression even over a relatively short time interval, and the potential utility to be applied to clinical trials of putative disease-modifying therapies.
PURPOSE: To investigate whether there are any white matter changes in a 6-month follow-up of mild-moderate Alzheimer'spatients using diffusion tensor imaging (DTI). MATERIALS AND METHODS: We recruited 18 mild-moderate Alzheimer's diseasepatients and they underwent magnetic resonance imaging (MRI) at recruitment and at 6-month follow-up. Diffusion MRI images were processed using DTI-ToolKit to create a population-based tensor template. This template was integrated with a voxel-wise and atlas-based analysis in FSL to determine the magnitude and location of change in diffusion metrics over the 6-month follow-up period. RESULTS: There were significant widespread changes in diffusion metrics across the entire white matter skeleton (P < 0.001), 95% confidence interval (CI) difference in fractional anisotropy: -0.007 (-0.011, -0.002), mean diffusivity: 0.040 (0.023, 0.058), axial diffusivity: 0.015 (0.008, 0.022), radial diffusivity: 0.012 (0.006, 0.019), as well as regions of interest in the splenium and superior longitudinal fasciculus. CONCLUSION: Our findings show that diffusion metrics are altered in a 6-month follow-up period of mild-moderate Alzheimer'spatients, supporting the potential of DTI metrics to act as sensitive biomarkers for disease progression even over a relatively short time interval, and the potential utility to be applied to clinical trials of putative disease-modifying therapies.
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