| Literature DB >> 26228091 |
I I Poletaeva1, N M Surina2, Z A Kostina2, O V Perepelkina2, I B Fedotova2.
Abstract
The more recent history and main experimental data for the Krushinsky-Molodkina (KM) audiogenic rat strain are presented. The strain selection started in late 1940. Now this strain is inbred, and two new strains are maintained in a laboratory in parallel. These strains originated from KM×Wistar hybrids and were bred (starting from 2000) for no-seizure and intense audiogenic seizure phenotypes, respectively. The experimental evidences of audiogenic seizure physiology were accumulated in parallel with (and usually ahead of) data on other audiogenic-prone strains. The peculiar feature of the KM strain is its vulnerability to brain hemorrhages. Thus, the KM strain is used not only as a genetic model of seizure states, but also as a model of blood flow disturbances in the brain. This article is part of a Special Issue entitled "Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic".Entities:
Keywords: Audiogenic seizure; Brain hemorrhage; Brain neurotransmitters; Epilepsy mechanisms; Inbred status; Oxidative stress; Rat strain
Mesh：
Year: 2015 PMID： 26228091 DOI： 10.1016/j.yebeh.2015.04.072
Source DB: PubMed Journal: Epilepsy Behav ISSN： 1525-5050 Impact factor: 2.937