Halil Atas1, Alper Kepez2, Mehmet Bozbay2, Dilek Seckin Gencosmanoglu3, Altug Cincin2, Murat Sunbul2, Ayfer Yildiz Bozbay4, Ramila Darvishova2, Tulin Ergun3. 1. Department of Cardiology, Marmara University Training and Research Hospital, Istanbul, Turkey. dratashalil@gmail.com. 2. Department of Cardiology, Marmara University Training and Research Hospital, Istanbul, Turkey. 3. Department of Dermatology, Marmara University Training and Research Hospital, Istanbul, Turkey. 4. Faculty of Medicine Hospital, Department of Dermatology, Fatih University, Istanbul, Turkey.
Abstract
BACKGROUND: Left atrial (LA) volume has been identified as a predictor of adverse cardiovascular outcomes, both in the general population and in selected clinical conditions. The aim of this study was to evaluate the effect of psoriasis on LA volume and mechanical function. METHODS: A total of 40 consecutive normotensive psoriasis patients free of any cardiovascular disease and 39 healthy volunteers were included. All participants underwent comprehensive transthoracic echocardiographic examination. LA volume and mechanical function were evaluated using real-time three-dimensional echocardiography (RT3DE). RESULTS: There were no significant differences between psoriasis and control groups with regard to conventional echocardiographic parameters. Individuals with psoriasis had a higher incidence of left ventricular diastolic dysfunction (LVDD) than the controls; nine people with psoriasis (23%) and three control individuals (8%) had LVDD (p = 0.06). With regard to the parameters obtained from RT3DE, LA maximum, LA minimum, passive stroke volume, and passive emptying fraction were significantly higher; whereas LA active emptying fraction, LA total emptying fraction, LA expansion index, and active stroke volume values were significantly lower in individuals with psoriasis compared with controls. Disease duration and Psoriasis Area of Severity Index (PASI) score correlated with the majority of volume parameters. CONCLUSION: Individuals with psoriasis had higher LA phasic volumes and impaired LA mechanical function compared with healthy controls. LA volume and functional analysis with RT3DE may facilitate recognition of subtle LA dysfunction in patients with psoriasis.
BACKGROUND: Left atrial (LA) volume has been identified as a predictor of adverse cardiovascular outcomes, both in the general population and in selected clinical conditions. The aim of this study was to evaluate the effect of psoriasis on LA volume and mechanical function. METHODS: A total of 40 consecutive normotensive psoriasispatients free of any cardiovascular disease and 39 healthy volunteers were included. All participants underwent comprehensive transthoracic echocardiographic examination. LA volume and mechanical function were evaluated using real-time three-dimensional echocardiography (RT3DE). RESULTS: There were no significant differences between psoriasis and control groups with regard to conventional echocardiographic parameters. Individuals with psoriasis had a higher incidence of left ventricular diastolic dysfunction (LVDD) than the controls; nine people with psoriasis (23%) and three control individuals (8%) had LVDD (p = 0.06). With regard to the parameters obtained from RT3DE, LA maximum, LA minimum, passive stroke volume, and passive emptying fraction were significantly higher; whereas LA active emptying fraction, LA total emptying fraction, LA expansion index, and active stroke volume values were significantly lower in individuals with psoriasis compared with controls. Disease duration and Psoriasis Area of Severity Index (PASI) score correlated with the majority of volume parameters. CONCLUSION: Individuals with psoriasis had higher LA phasic volumes and impaired LA mechanical function compared with healthy controls. LA volume and functional analysis with RT3DE may facilitate recognition of subtle LA dysfunction in patients with psoriasis.
Entities:
Keywords:
Left atrial contractility; Left atrial mechanical function; Left atrial volume; Psoriasis; Real-time three-dimensional echocardiography
Authors: Sherif F Nagueh; Christopher P Appleton; Thierry C Gillebert; Paolo N Marino; Jae K Oh; Otto A Smiseth; Alan D Waggoner; Frank A Flachskampf; Patricia A Pellikka; Arturo Evangelista Journal: J Am Soc Echocardiogr Date: 2009-02 Impact factor: 5.251
Authors: O Ahlehoff; G H Gislason; M Charlot; C H Jørgensen; J Lindhardsen; J B Olesen; S Z Abildstrøm; L Skov; C Torp-Pedersen; P R Hansen Journal: J Intern Med Date: 2010-11-29 Impact factor: 8.989
Authors: Emine Bilen; Mustafa Kurt; Ibrahim Halil Tanboğa; Umran Koçak; Hüseyin Ayhan; Tahir Durmaz; Engin Bozkurt Journal: Turk Kardiyol Dern Ars Date: 2012-03
Authors: S Coimbra; H Oliveira; F Reis; L Belo; S Rocha; A Quintanilha; A Figueiredo; F Teixeira; E Castro; P Rocha-Pereira; A Santos-Silva Journal: J Eur Acad Dermatol Venereol Date: 2009-12-11 Impact factor: 6.166