Sushant M Ranadive1, Huimin Yan, Abbi D Lane, Rebecca M Kappus, Marc D Cook, Peng Sun, Idethia Harvey, Robert Ploutz-Synder, Jeffrey A Woods, Kenneth R Wilund, B O Fernhall. 1. 1Department of Anesthesiology, Mayo Clinic, Rochester, MN; 2Department of Kinesiology and Community Health, Urbana, IL; 3Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL; 4Department of Health and Kinesiology Transdisciplinary Center on Health Equity Research, Texas A&M University, College Station, TX; and 5Division of Space Life Sciences, Universities Space Research Association, Houston, TX.
Abstract
UNLABELLED: African Americans (AA) have increased carotid artery intima-media thickness and decreased vascular function compared with their Caucasian (CA) peers. Aerobic exercise prevents and potentially reverses arterial dysfunction. PURPOSE: The purpose of this study was to examine the effect of 8 wk of moderate- to high-intensity aerobic training in young healthy sedentary AA and CA men and women. METHODS:Sixty-four healthy volunteers (men, 28; women, 36) with mean age 24 yr underwent measures of arterial structure, function, and blood pressure (BP) variables at baseline, after the 4-wk control period, and 8 wk after training. RESULTS: There was a significant increase in VO2peak among both groups after exercise training. Brachial systolic BP decreased significantly after the control period in both groups but not after exercise training. Carotid pulse pressure decreased significantly in both groups after exercise training as compared with that in baseline. There was no change in any of the other BP variables. AA had higher intima-media thickness at baseline and after the control period but it significantly decreased after exercise training compared with that of CA. AA had significantly lower baseline forearm blood flow and reactive hyperemia compared with those of CA, but exercise training had no effect on these variables. There was no significant difference in arterial stiffness (central pulse wave velocity) and wave-reflection (augmentation index) between the two groups at any time point. CONCLUSIONS: This is the first study to show that 8 wk of aerobic exercise training causes significant improvement in the arterial structure in young, healthy AA, making it comparable with the CA and with minimal effects on BP variables.
RCT Entities:
UNLABELLED: African Americans (AA) have increased carotid artery intima-media thickness and decreased vascular function compared with their Caucasian (CA) peers. Aerobic exercise prevents and potentially reverses arterial dysfunction. PURPOSE: The purpose of this study was to examine the effect of 8 wk of moderate- to high-intensity aerobic training in young healthy sedentary AA and CA men and women. METHODS: Sixty-four healthy volunteers (men, 28; women, 36) with mean age 24 yr underwent measures of arterial structure, function, and blood pressure (BP) variables at baseline, after the 4-wk control period, and 8 wk after training. RESULTS: There was a significant increase in VO2peak among both groups after exercise training. Brachial systolic BP decreased significantly after the control period in both groups but not after exercise training. Carotid pulse pressure decreased significantly in both groups after exercise training as compared with that in baseline. There was no change in any of the other BP variables. AA had higher intima-media thickness at baseline and after the control period but it significantly decreased after exercise training compared with that of CA. AA had significantly lower baseline forearm blood flow and reactive hyperemia compared with those of CA, but exercise training had no effect on these variables. There was no significant difference in arterial stiffness (central pulse wave velocity) and wave-reflection (augmentation index) between the two groups at any time point. CONCLUSIONS: This is the first study to show that 8 wk of aerobic exercise training causes significant improvement in the arterial structure in young, healthy AA, making it comparable with the CA and with minimal effects on BP variables.
Authors: Daniel J Green; Nicola Rowley; Angela Spence; Howard Carter; Greg Whyte; Keith George; Louise H Naylor; N Timothy Cable; Ellen A Dawson; Dick H J Thijssen Journal: Med Sci Sports Exerc Date: 2013-01 Impact factor: 5.411
Authors: Dick H J Thijssen; Ellen A Dawson; Inge C L van den Munckhof; Gurpreet K Birk; N Timothy Cable; Daniel J Green Journal: Atherosclerosis Date: 2013-05-21 Impact factor: 5.162
Authors: Huimin Yan; Sushant M Ranadive; Kevin S Heffernan; Abbi D Lane; Rebecca M Kappus; Marc D Cook; Pei-Tzu Wu; Peng Sun; Idethia S Harvey; Jeffrey A Woods; Kenneth R Wilund; Bo Fernhall Journal: Am J Physiol Heart Circ Physiol Date: 2013-11-01 Impact factor: 4.733
Authors: Elizabeth C Schroeder; Sushant M Ranadive; Huimin Yan; Abbi D Lane-Cordova; Rebecca M Kappus; Marc D Cook; Bo Fernhall Journal: J Hypertens Date: 2019-06 Impact factor: 4.844
Authors: Linda S Pescatello; Elizabeth D Schifano; Garrett I Ash; Gregory A Panza; Lauren M L Corso; Ming-Hui Chen; Ved Deshpande; Amanda Zaleski; Burak Cilhoroz; Paulo Farinatti; Beth A Taylor; Rachel J O'Neill; Paul D Thompson Journal: Physiol Rep Date: 2017-11