Literature DB >> 26225574

BioCartilage: A New Biomaterial to Treat Chondral Lesions.

Alan M Hirahara1, Kenneth W Mueller.   

Abstract

Articular cartilage damage affects almost everyone at some point. Our ability to heal these defects has been very limited. Microfracture, which is one of the most common attempted surgeries for chondral lesions, has resulted in poor long-term outcomes. Other solutions like allograft osteochondral autograft transfer system, DeNovo, or autologous chondrocyte implantation are more extensive, difficult, expensive surgeries, and are better served for larger lesions. Smaller lesions have shown good short-term outcomes with microfracture but result in creation of fibrocartilage, which is weaker and softer and does not hold up long term. A simple, inexpensive, longer-term solution is needed. BioCartilage is dehydrated, micronized allogeneic cartilage that can be implanted with platelet-rich plasma into these smaller cartilage defects. BioCartilage acts as scaffold, allowing for the creation of hyaline-like cartilage.

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Year:  2015        PMID: 26225574     DOI: 10.1097/JSA.0000000000000071

Source DB:  PubMed          Journal:  Sports Med Arthrosc Rev        ISSN: 1062-8592            Impact factor:   1.985


  9 in total

Review 1.  Engineering Stem and Stromal Cell Therapies for Musculoskeletal Tissue Repair.

Authors:  Claudia Loebel; Jason A Burdick
Journal:  Cell Stem Cell       Date:  2018-02-08       Impact factor: 24.633

2.  Wide Variation in Methodology in Level I and II Studies on Cartilage Repair: A Systematic Review of Available Clinical Trials Comparing Patient Demographics, Treatment Means, and Outcomes Reporting.

Authors:  Bryan Michael Saltzman; Michael L Redondo; Adam Beer; Eric J Cotter; Rachel M Frank; Adam B Yanke; Brian J Cole
Journal:  Cartilage       Date:  2018-10-31       Impact factor: 4.634

3.  Early loss of subchondral bone following microfracture is counteracted by bone marrow aspirate in a translational model of osteochondral repair.

Authors:  Liang Gao; Patrick Orth; Kathrin Müller-Brandt; Lars K H Goebel; Magali Cucchiarini; Henning Madry
Journal:  Sci Rep       Date:  2017-03-27       Impact factor: 4.379

4.  The clot thickens: Autologous and allogeneic fibrin sealants are mechanically equivalent in an ex vivo model of cartilage repair.

Authors:  Rebecca M Irwin; Lawrence J Bonassar; Itai Cohen; Andrea M Matuska; Jacqueline Commins; Brian Cole; Lisa A Fortier
Journal:  PLoS One       Date:  2019-11-08       Impact factor: 3.240

5.  Improved Outcomes with Arthroscopic Bone Marrow Aspirate Concentrate and Cartilage-Derived Matrix Implantation versus Chondroplasty for the Treatment of Focal Chondral Defects of the Knee Joint: A Retrospective Case Series.

Authors:  Iciar M Dávila Castrodad; Matthew J Kraeutler; Sydney M Fasulo; Anthony Festa; Vincent K McInerney; Anthony J Scillia
Journal:  Arthrosc Sports Med Rehabil       Date:  2021-12-23

Review 6.  Osteochondral scaffolds for early treatment of cartilage defects in osteoarthritic joints: from bench to clinic.

Authors:  Maryam Tamaddon; Helena Gilja; Ling Wang; J Miguel Oliveira; Xiaodan Sun; Rongwei Tan; Chaozong Liu
Journal:  Biomater Transl       Date:  2020-12-28

7.  Arthroscopic Treatment of Hip Chondral Defect With Microfracture and Platelet-Rich Plasma-Infused Micronized Cartilage Allograft Augmentation.

Authors:  Michael S Schallmo; Alejandro Marquez-Lara; T David Luo; Samuel Rosas; Allston J Stubbs
Journal:  Arthrosc Tech       Date:  2018-03-19

8.  Arthroscopic Treatment of Osteochondral Lesions of the Talus With Microfracture and Platelet-Rich Plasma-Infused Micronized Cartilage Allograft.

Authors:  Daniel J Cunningham; Samuel B Adams
Journal:  Arthrosc Tech       Date:  2020-04-10

9.  Single-Stage Arthroscopic Autologous Matrix-Enhanced Chondral Transplantation (AMECT) in the Hip.

Authors:  Matthew J Craig; Travis G Maak
Journal:  Arthrosc Tech       Date:  2020-02-25
  9 in total

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