PURPOSE: The goal of this study was to establish normative values for measurements of quantitative pupillometry in children. METHODS: Quantitative pupillometry measurements were obtained from children between 1 and 18 years of age being seen for either a well child check or other outpatient appointment. RESULTS: Maximum and minimum pupil size increased slightly with age; however, the correlation was weak (r = 0.29 and 0.19, respectively). Similarly weak correlations with age also were observed for maximum constriction velocity (r = -0.29) and dilation velocity (r = 0.27). Maximum (5.56 vs. 4.97 mm) and minimum (3.74 vs. 3.40 mm) pupil sizes were significantly larger in whites than in African Americans. CONCLUSIONS: Pupil size and reactivity show little correlation with age and are therefore suitable for further exploration in using pupillometry as a biomarker across the pediatric age range. Differences in race should be taken into consideration when pupillometry is used in mixed populations.
PURPOSE: The goal of this study was to establish normative values for measurements of quantitative pupillometry in children. METHODS: Quantitative pupillometry measurements were obtained from children between 1 and 18 years of age being seen for either a well child check or other outpatient appointment. RESULTS: Maximum and minimum pupil size increased slightly with age; however, the correlation was weak (r = 0.29 and 0.19, respectively). Similarly weak correlations with age also were observed for maximum constriction velocity (r = -0.29) and dilation velocity (r = 0.27). Maximum (5.56 vs. 4.97 mm) and minimum (3.74 vs. 3.40 mm) pupil sizes were significantly larger in whites than in African Americans. CONCLUSIONS: Pupil size and reactivity show little correlation with age and are therefore suitable for further exploration in using pupillometry as a biomarker across the pediatric age range. Differences in race should be taken into consideration when pupillometry is used in mixed populations.
Authors: Molly Winston; Amy Zhou; Casey M Rand; Emma C Dunne; Justin J Warner; Lena J Volpe; Brooke A Pigneri; Drew Simon; Thomas Bielawiec; Samantha C Gordon; Sally F Vitez; Aaron Charnay; Stephen Joza; Kristen Kelly; Cia Panicker; Saajidha Rizvydeen; Grace Niewijk; Cara Coleman; Bradley J Scher; David W Reed; Sara M Hockney; Gigi Buniao; Tracey Stewart; Lynne Trojanowski; Cindy Brogadir; Michelle Price; Anna S Kenny; Allison Bradley; Nicholas J Volpe; Debra E Weese-Mayer Journal: Clin Auton Res Date: 2019-09-25 Impact factor: 4.435