Olga Charyeva1,2, Ulrich Thormann1,3, Katrin S Lips1, Lydia Heimann2, Ursula Sommer1, Gabor Szalay3, Volker Alt1,3, Norbert Hort4, Reinhard Schnettler1,3, Michael Rauschmann5, Sven Schmidt5. 1. BFS, Laboratory for Experimental Trauma Surgery, Justus-Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, Germany. 2. aap Biomaterials GmbH, Lagerstrasse 11-15, 64807 Dieburg, Germany. 3. Department of Trauma Surgery, University Hospital of Giessen-Marburg, Rudolf-Buchheim-Str. 9, 35385 Giessen, Germany. 4. Magnesium Innovation Centre, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, 21502 Geesthacht, Germany. 5. Orthopaedic University Hospital Friedrichsheim, Marienburgstr. 2, 60528 Frankfurt on Main, Germany.
Abstract
BACKGROUND: A variety of materials have been used for bone augmentation, distraction osteotomy, and in post-cancer patients following tumor removal. However, a temporary metal implant that would resorb after successful treatment is a new concept. Magnesium was suggested as a suitable material for these purposes because it is biocompatible, has better mechanical properties than titanium, and stimulates new bone formation. This study evaluates histological appearance of magnesium-based implants and the surrounding bone. MATERIALS AND METHODS: Three magnesium-based biomaterials were tested in a rabbit bone defect model: magnesium-hydroxyapatite (Mg-HA), W4 (96 % magnesium, 4 % yttrium), and pure magnesium (pure Mg). Animals were sacrificed after 6 and 12 weeks and the samples were analyzed histologically and histomorphometrically. RESULTS: Mg-HA had the highest mean amount of tartrate-resistant acid phosphatase (TRAP) positive cells at the implantation site of all groups. It had shown the fastest degradation rate already at 6 weeks but the least amount of new bone formation. New bone was seen forming in direct contact with pure Mg and W4. The mean gas volume was highest in W4 compared to pure Mg and Mg-HA but this difference was not statistically significant. W4 had the lowest mean number of TRAP-positive cells of all materials. CONCLUSION: Pure Mg and W4 were shown to be the most promising materials in this study in respect to the bone response to the implant material. They could be used for screws and plates in bone augmentation procedures.
BACKGROUND: A variety of materials have been used for bone augmentation, distraction osteotomy, and in post-cancerpatients following tumor removal. However, a temporary metal implant that would resorb after successful treatment is a new concept. Magnesium was suggested as a suitable material for these purposes because it is biocompatible, has better mechanical properties than titanium, and stimulates new bone formation. This study evaluates histological appearance of magnesium-based implants and the surrounding bone. MATERIALS AND METHODS: Three magnesium-based biomaterials were tested in a rabbit bone defect model: magnesium-hydroxyapatite (Mg-HA), W4 (96 % magnesium, 4 % yttrium), and pure magnesium (pure Mg). Animals were sacrificed after 6 and 12 weeks and the samples were analyzed histologically and histomorphometrically. RESULTS:Mg-HA had the highest mean amount of tartrate-resistant acid phosphatase (TRAP) positive cells at the implantation site of all groups. It had shown the fastest degradation rate already at 6 weeks but the least amount of new bone formation. New bone was seen forming in direct contact with pure Mg and W4. The mean gas volume was highest in W4 compared to pure Mg and Mg-HA but this difference was not statistically significant. W4 had the lowest mean number of TRAP-positive cells of all materials. CONCLUSION: Pure Mg and W4 were shown to be the most promising materials in this study in respect to the bone response to the implant material. They could be used for screws and plates in bone augmentation procedures.
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Authors: Michael Grau; Christian Seiler; Laura Roland; Julia Matena; Claudia Windhövel; Michael Teske; Hugo Murua Escobar; Matthias Lüpke; Hermann Seifert; Nils-Claudius Gellrich; Heinz Haferkamp; Ingo Nolte Journal: Materials (Basel) Date: 2017-12-21 Impact factor: 3.623
Authors: Laura Roland; Michael Grau; Julia Matena; Michael Teske; Matthias Gieseke; Andreas Kampmann; Martin Beyerbach; Hugo Murua Escobar; Heinz Haferkamp; Nils-Claudius Gellrich; Ingo Nolte Journal: Int J Mol Sci Date: 2015-12-22 Impact factor: 5.923