INTRODUCTION: Simvastatin, a common cholesterol-lowering drug that inhibits hepatic hydroxymethylglutaryl coenzyme A reductase, the rate-limiting enzyme in the mevalonate pathway, increases expression of the BMP-2 gene and thus promotes bone regeneration. MATERIALS AND METHODS: A study was conducted in mandibular third molar sockets to study the efficacy of the drug by implanting it into sockets (experimental group) and observations were made over 3 months to compare the healing with the (control group). CONCLUSION: The results showed faster regeneration of the bone in the simvastatin site using the gray level histogram values.
INTRODUCTION:Simvastatin, a common cholesterol-lowering drug that inhibits hepatic hydroxymethylglutaryl coenzyme A reductase, the rate-limiting enzyme in the mevalonate pathway, increases expression of the BMP-2 gene and thus promotes bone regeneration. MATERIALS AND METHODS: A study was conducted in mandibular third molar sockets to study the efficacy of the drug by implanting it into sockets (experimental group) and observations were made over 3 months to compare the healing with the (control group). CONCLUSION: The results showed faster regeneration of the bone in the simvastatin site using the gray level histogram values.
Entities:
Keywords:
Bone regeneration; Simvastatin; Third molar sockets
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