Literature DB >> 26224894

Steroid Receptor-Associated Immunophilins: A Gateway to Steroid Signalling.

Thomas Ratajczak1, Carmel Cluning1, Bryan K Ward1.   

Abstract

The steroid receptor-associated immunophilins FKBP51, FKBP52, CyP40 and PP5 have specific roles in steroid receptor function that impact steroid hormone-binding affinity, nucleocytoplasmic shuttling and transcriptional activation of target genes in a tissue-specific manner. Aberrant expression of these functionally unique immunophilins has the potential to cause steroid-based diseases, including breast and prostate cancer, diabetes and related metabolic disorders, male and female infertility and major depressive disorders. This review addresses the function of these proteins as co-chaperones in steroid receptor-Hsp90 complexes and extensively covers current knowledge of the link between the steroid receptor-associated immunophilins and human disease. An improved understanding of their mechanisms of action has revealed opportunities for molecular therapies to enhance or inhibit cellular processes under immunophilin control that contribute both to human health and disease.

Entities:  

Year:  2015        PMID： 26224894      PMCID： PMC4504154     

Source DB:  PubMed          Journal:  Clin Biochem Rev        ISSN： 0159-8090


  212 in total

1.  FKBP4 is regulated by HOXA10 during decidualization and in endometriosis.

Authors:  Huan Yang; Yuping Zhou; Benjiamin Edelshain; Frederick Schatz; Charles J Lockwood; Hugh S Taylor
Journal:  Reproduction       Date:  2012-01-25       Impact factor: 3.906

Review 2.  Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.

Authors:  Komal Jhaveri; Tony Taldone; Shanu Modi; Gabriela Chiosis
Journal:  Biochim Biophys Acta       Date:  2011-10-29

3.  Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.

Authors:  K Morita; M Saitoh; K Tobiume; H Matsuura; S Enomoto; H Nishitoh; H Ichijo
Journal:  EMBO J       Date:  2001-11-01       Impact factor: 11.598

4.  Modulation of glucocorticoid receptor phosphorylation and transcriptional activity by a C-terminal-associated protein phosphatase.

Authors:  Zhen Wang; Weiwei Chen; Evelyn Kono; Thoa Dang; Michael J Garabedian
Journal:  Mol Endocrinol       Date:  2006-12-21

5.  The structure and complete nucleotide sequence of the human cyclophilin 40 (PPID) gene.

Authors:  H Yokoi; Y Shimizu; H Anazawa; C A Lefebvre; R G Korneluk; J E Ikeda
Journal:  Genomics       Date:  1996-08-01       Impact factor: 5.736

6.  Deficiency of immunophilin FKBP52 promotes endometriosis.

Authors:  Yasushi Hirota; Susanne Tranguch; Takiko Daikoku; Akiko Hasegawa; Yutaka Osuga; Yuji Taketani; Sudhansu K Dey
Journal:  Am J Pathol       Date:  2008-11-06       Impact factor: 4.307

7.  A heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock response.

Authors:  Jeanette R McConnell; Leslie A Alexander; Shelli R McAlpine
Journal:  Bioorg Med Chem Lett       Date:  2013-12-01       Impact factor: 2.823

Review 8.  Hsp90: an emerging target for breast cancer therapy.

Authors:  Jason Beliakoff; Luke Whitesell
Journal:  Anticancer Drugs       Date:  2004-08       Impact factor: 2.248

9.  FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.

Authors:  Huadong Pei; Liang Li; Brooke L Fridley; Gregory D Jenkins; Krishna R Kalari; Wilma Lingle; Gloria Petersen; Zhenkun Lou; Liewei Wang
Journal:  Cancer Cell       Date:  2009-09-08       Impact factor: 31.743

10.  The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort.

Authors:  Magnus Lekman; Gonzalo Laje; Dennis Charney; A John Rush; Alexander F Wilson; Alexa J M Sorant; Robert Lipsky; Stephen R Wisniewski; Husseini Manji; Francis J McMahon; Silvia Paddock
Journal:  Biol Psychiatry       Date:  2008-01-11       Impact factor: 13.382
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  18 in total

1.  Hsp90-binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity.

Authors:  Mariana Lagadari; Nadia R Zgajnar; Luciana I Gallo; Mario D Galigniana
Journal:  Mol Oncol       Date:  2016-05-17       Impact factor: 6.603

2.  N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer.

Authors:  Etienne Dardenne; Himisha Beltran; Matteo Benelli; Kaitlyn Gayvert; Adeline Berger; Loredana Puca; Joanna Cyrta; Andrea Sboner; Zohal Noorzad; Theresa MacDonald; Cynthia Cheung; Ka Shing Yuen; Dong Gao; Yu Chen; Martin Eilers; Juan-Miguel Mosquera; Brian D Robinson; Olivier Elemento; Mark A Rubin; Francesca Demichelis; David S Rickman
Journal:  Cancer Cell       Date:  2016-10-10       Impact factor: 31.743

3.  Relation of adipose tissue and skeletal muscle FKBP5 expression with insulin sensitivity and the regulation of FKBP5 by insulin and free fatty acids.

Authors:  Marek Strączkowski; Magdalena Stefanowicz; Natalia Matulewicz; Agnieszka Nikołajuk; Monika Karczewska-Kupczewska
Journal:  Endocrine       Date:  2022-02-25       Impact factor: 3.925

Review 4.  Glucocorticoid-independent modulation of GR activity: Implications for immunotherapy.

Authors:  Janet P Hapgood; Chanel Avenant; Johnson M Moliki
Journal:  Pharmacol Ther       Date:  2016-06-08       Impact factor: 12.310

5.  Experience and activity-dependent control of glucocorticoid receptors during the stress response in large-scale brain networks.

Authors:  Damien Huzard; Virginie Rappeneau; Onno C Meijer; Chadi Touma; Margarita Arango-Lievano; Michael J Garabedian; Freddy Jeanneteau
Journal:  Stress       Date:  2020-08-26       Impact factor: 3.493

Review 6.  The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease.

Authors:  Gabriel R Fries; Nils C Gassen; Theo Rein
Journal:  Int J Mol Sci       Date:  2017-12-05       Impact factor: 5.923

7.  Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function.

Authors:  Georgia Balsevich; Alexander S Häusl; Carola W Meyer; Stoyo Karamihalev; Xixi Feng; Max L Pöhlmann; Carine Dournes; Andres Uribe-Marino; Sara Santarelli; Christiana Labermaier; Kathrin Hafner; Tianqi Mao; Michaela Breitsamer; Marily Theodoropoulou; Christian Namendorf; Manfred Uhr; Marcelo Paez-Pereda; Gerhard Winter; Felix Hausch; Alon Chen; Matthias H Tschöp; Theo Rein; Nils C Gassen; Mathias V Schmidt
Journal:  Nat Commun       Date:  2017-11-23       Impact factor: 14.919

8.  Natural Mating Differentially Triggers Expression of Glucocorticoid Receptor (NR3C1)-Related Genes in the Preovulatory Porcine Female Reproductive Tract.

Authors:  Mateo Ruiz-Conca; Jaume Gardela; Cristina Alicia Martínez; Dominic Wright; Manel López-Bejar; Heriberto Rodríguez-Martínez; Manuel Álvarez-Rodríguez
Journal:  Int J Mol Sci       Date:  2020-06-22       Impact factor: 5.923

9.  Glucocorticoid receptor mutations and clinical sensitivity to glucocorticoid in Chinese multiple sclerosis patients.

Authors:  Tian Song; Haoxiao Chang; Li Du; Linlin Yin; Fudong Shi; Xinghu Zhang
Journal:  Neurol Sci       Date:  2020-04-10       Impact factor: 3.307

Review 10.  Disease- and treatment-associated acquired glucocorticoid resistance.

Authors:  Legh Wilkinson; Nicolette J D Verhoog; Ann Louw
Journal:  Endocr Connect       Date:  2018-12       Impact factor: 3.335
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