Literature DB >> 26224874

Imaging Tumor Acidity: pH-Low Insertion Peptide Probe for Optoacoustic Tomography.

Yana K Reshetnyak1.   

Abstract

Optoacoustic tomography has been used for the detection of pancreatic ductal adenocarcinoma targeted by pH-low insertion peptide (pHLIP) conjugated to near-infrared fluorescent dye. It was proved that tumor targeting is pH dependent. The approach could have major implication for detection and monitoring of pancreatic and other cancers. ©2015 American Association for Cancer Research.

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Year:  2015        PMID: 26224874      PMCID: PMC4609264          DOI: 10.1158/1078-0432.CCR-15-1502

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN: 1078-0432            Impact factor:   12.531


  12 in total

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3.  Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo.

Authors:  Charles W Kimbrough; Anil Khanal; Matthew Zeiderman; Bigya R Khanal; Neal C Burton; Kelly M McMasters; Selwyn M Vickers; William E Grizzle; Lacey R McNally
Journal:  Clin Cancer Res       Date:  2015-06-29       Impact factor: 12.531

4.  Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation.

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5.  Family of pH (low) insertion peptides for tumor targeting.

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Review 8.  pH sensing and regulation in cancer.

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Journal:  Front Physiol       Date:  2013-12-17       Impact factor: 4.566

Review 9.  Targeting diseased tissues by pHLIP insertion at low cell surface pH.

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7.  Extracellular Acidosis Promotes Metastatic Potency via Decrease of the BMAL1 Circadian Clock Gene in Breast Cancer.

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