Literature DB >> 26224597

Huntington's disease--the sting in the tail.

Maria Jimenez-Sanchez1, David C Rubinsztein1.   

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Year:  2015        PMID： 26224597      PMCID： PMC4585458          DOI： 10.15252/embj.201592467

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


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  9 in total

1.  Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum.

Authors:  L M Mende-Mueller; T Toneff; S R Hwang; M F Chesselet; V Y Hook
Journal:  J Neurosci       Date:  2001-03-15       Impact factor: 6.167

2.  Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.

Authors:  M DiFiglia; E Sapp; K O Chase; S W Davies; G P Bates; J P Vonsattel; N Aronin
Journal:  Science       Date:  1997-09-26       Impact factor: 47.728

3.  Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Authors:  Rona K Graham; Yu Deng; Elizabeth J Slow; Brendan Haigh; Nagat Bissada; Ge Lu; Jacqueline Pearson; Jacqueline Shehadeh; Lisa Bertram; Zoe Murphy; Simon C Warby; Crystal N Doty; Sophie Roy; Cheryl L Wellington; Blair R Leavitt; Lynn A Raymond; Donald W Nicholson; Michael R Hayden
Journal:  Cell       Date:  2006-06-16       Impact factor: 41.582

4.  Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.

Authors:  L Mangiarini; K Sathasivam; M Seller; B Cozens; A Harper; C Hetherington; M Lawton; Y Trottier; H Lehrach; S W Davies; G P Bates
Journal:  Cell       Date:  1996-11-01       Impact factor: 41.582

5.  Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

Authors:  Marie-Thérèse El-Daher; Emilie Hangen; Julie Bruyère; Ghislaine Poizat; Ismael Al-Ramahi; Raul Pardo; Nicolas Bourg; Sylvie Souquere; Céline Mayet; Gérard Pierron; Sandrine Lévêque-Fort; Juan Botas; Sandrine Humbert; Frédéric Saudou
Journal:  EMBO J       Date:  2015-07-12       Impact factor: 11.598

6.  A cellular model that recapitulates major pathogenic steps of Huntington's disease.

Authors:  A Lunkes; J L Mandel
Journal:  Hum Mol Genet       Date:  1998-09       Impact factor: 6.150

7.  Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.

Authors:  Kirupa Sathasivam; Andreas Neueder; Theresa A Gipson; Christian Landles; Agnesska C Benjamin; Marie K Bondulich; Donna L Smith; Richard L M Faull; Raymund A C Roos; David Howland; Peter J Detloff; David E Housman; Gillian P Bates
Journal:  Proc Natl Acad Sci U S A       Date:  2013-01-22       Impact factor: 11.205

8.  Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions.

Authors:  Astrid Lunkes; Katrin S Lindenberg; Léa Ben-Haïem; Chantal Weber; Didier Devys; G Bernhard Landwehrmeyer; Jean-Louis Mandel; Yvon Trottier
Journal:  Mol Cell       Date:  2002-08       Impact factor: 17.970

9.  Huntingtin functions as a scaffold for selective macroautophagy.

Authors:  Yan-Ning Rui; Zhen Xu; Bindi Patel; Zhihua Chen; Dongsheng Chen; Antonio Tito; Gabriela David; Yamin Sun; Erin F Stimming; Hugo J Bellen; Ana Maria Cuervo; Sheng Zhang
Journal:  Nat Cell Biol       Date:  2015-02-16       Impact factor: 28.824
  9 in total

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