| Literature DB >> 26224360 |
Xi-Chang Liu1,2,3, Li-Yan Jing4, Ming-Feng Yang2, Kun Wang2,5, Yuan Wang6, Xiao-Yan Fu7, Jie Fang2, Ya-Jun Hou2, Jing-Yi Sun7, Da-Wei Li2, Zong-Yong Zhang2, Lei-Lei Mao2, You-Mei Tang3, Xiao-Ting Fu2, Cun-Dong Fan8, Xiao-Yi Yang2, Bao-Liang Sun9,10,11.
Abstract
Hypothermia treatment is one of the neuroprotective strategies that improve neurological outcomes effectively after brain damage. Minimally invasive surgery (MIS) has been an important treatment of intracerebral hemorrhage (ICH). Herein, we evaluated the neuroprotective effect and mechanism of MIS joint local cooling lavage (LCL) treatment on ICH via detecting the inflammatory responses, oxidative injury, and neuronal apoptosis around the hematoma cavity in rats. ICH model was established by type IV collagenase caudatum infusion. The rats were treated with MIS 6 h after injection, and then were lavaged by normothermic (37 °C) and hypothermic (33 °C) normal saline in brain separately. The results indicated that MIS joint LCL treatment showed enhanced therapeutic effects against ICH-induced inflammation injury and apoptosis in rats, as convinced by the decline of TUNEL-positive cells, followed by the decrease of IL-1β and LDH and increase of IL-10 and SOD. This study demonstrated that the strategy of using MIS joint LCL may achieve enhanced neuroprotection against ICH-induced inflammation injury and apoptosis in rats with potential clinic application.Entities:
Keywords: Intracerebral hemorrhage; Local cooling lavage; Minimally invasive surgery; Neuronal cell apoptosis
Mesh：
Year: 2015 PMID： 26224360 DOI： 10.1007/s10571-015-0245-z
Source DB: PubMed Journal: Cell Mol Neurobiol ISSN： 0272-4340 Impact factor: 5.046