Elizabeth V Arkema1,2, Bing Lu1, Susan Malspeis1, Elizabeth W Karlson1, Karen H Costenbader1. 1. Division of Rheumatology, Immunology & Allergy, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. 2. Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Abstract
OBJECTIVE: To examine monocyte chemotactic protein-1 (MCP-1) concentration and future rheumatoid arthritis (RA) risk, and investigate effect modification by human leukocyte antigen-shared epitope (HLA-SE) and several lifestyle factors. METHODS: We conducted a nested case-control study using stored plasma samples from the Nurses' Health Studies. Each pre-RA case was matched to three controls (N case = 220, N control = 675). Odds ratios (OR) for RA associated with MCP-1 concentration and interactions with HLA-SE, smoking, BMI and alcohol intake were estimated. RESULTS: MCP-1 concentration was associated with both seropositive and seronegative RA, in particular <5 years of blood draw (OR: 2.42), and among HLA-SE positive (OR: 2.05). No interactions with smoking, BMI or alcohol were detected. CONCLUSION: MCP-1 was associated with risk of RA, especially among HLA-SE positive, but did not differ by smoking status, BMI or alcohol intake.
OBJECTIVE: To examine monocyte chemotactic protein-1 (MCP-1) concentration and future rheumatoid arthritis (RA) risk, and investigate effect modification by human leukocyte antigen-shared epitope (HLA-SE) and several lifestyle factors. METHODS: We conducted a nested case-control study using stored plasma samples from the Nurses' Health Studies. Each pre-RA case was matched to three controls (N case = 220, N control = 675). Odds ratios (OR) for RA associated with MCP-1 concentration and interactions with HLA-SE, smoking, BMI and alcohol intake were estimated. RESULTS:MCP-1 concentration was associated with both seropositive and seronegative RA, in particular <5 years of blood draw (OR: 2.42), and among HLA-SE positive (OR: 2.05). No interactions with smoking, BMI or alcohol were detected. CONCLUSION:MCP-1 was associated with risk of RA, especially among HLA-SE positive, but did not differ by smoking status, BMI or alcohol intake.
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