Literature DB >> 26223642

R5 Macrophage-Tropic HIV-1 in the Male Genital Tract.

Maria M Bednar1, Blake M Hauser1, Li-Hua Ping1, Elena Dukhovlinova1, Shuntai Zhou1, Kathryn T Arrildt2, Irving F Hoffman3, Joseph J Eron3, Myron S Cohen3, Ronald Swanstrom4.   

Abstract

The entry tropism of HIV-1 Env proteins from virus isolated from the blood and genital tract of five men with compartmentalized lineages was determined. The Env proteins isolated from the genital tract of subject C018 were macrophage-tropic proteins, while the remaining cloned env genes encoded R5 T cell-tropic proteins. The detection of a macrophage-tropic lineage of HIV-1 within the male genital tract strongly suggests that evolution of macrophage-tropic viruses can occur in anatomically isolated sites outside the central nervous system.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26223642      PMCID： PMC4580182          DOI： 10.1128/JVI.01842-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

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Authors:  M S Cohen; I F Hoffman; R A Royce; P Kazembe; J R Dyer; C C Daly; D Zimba; P L Vernazza; M Maida; S A Fiscus; J J Eron
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Journal:  J Virol       Date:  2000-10       Impact factor: 5.103

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Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-19       Impact factor: 11.205

7.  Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays.

Authors:  David C Montefiori
Journal:  Curr Protoc Immunol       Date:  2005-01

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Review 9.  Variation of macrophage tropism among HIV-1 R5 envelopes in brain and other tissues.

Authors:  Paul J Peters; Maria J Dueñas-Decamp; W Matthew Sullivan; Paul R Clapham
Journal:  J Neuroimmune Pharmacol       Date:  2006-11-07       Impact factor: 4.147

10.  Macrophage-tropic simian/human immunodeficiency virus chimeras use CXCR4, not CCR5, for infections of rhesus macaque peripheral blood mononuclear cells and alveolar macrophages.

Authors:  Tatsuhiko Igarashi; Olivia K Donau; Hiromi Imamichi; Marie-Jeanne Dumaurier; Reza Sadjadpour; Ronald J Plishka; Alicia Buckler-White; Charles Buckler; Anthony F Suffredini; H Clifford Lane; John P Moore; Malcolm A Martin
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103
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  5 in total

1.  HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.

Authors:  Briana Quitadamo; Paul J Peters; Alexander Repik; Olivia O'Connell; Zhongming Mou; Matthew Koch; Mohan Somasundaran; Robin Brody; Katherine Luzuriaga; Aaron Wallace; Shixia Wang; Shan Lu; Sean McCauley; Jeremy Luban; Maria Duenas-Decamp; Maria Paz Gonzalez-Perez; Paul R Clapham
Journal:  J Virol       Date:  2018-01-02       Impact factor: 5.103

2.  Deep Sequencing Reveals Compartmentalized HIV-1 in the Semen of Men with and without Sexually Transmitted Infection-Associated Urethritis.

Authors:  Olivia D Council; Shuntai Zhou; Chase D McCann; Irving Hoffman; Gerald Tegha; Deborah Kamwendo; Mitch Matoga; Sergei L Kosakovsky Pond; Myron S Cohen; Ronald Swanstrom
Journal:  J Virol       Date:  2020-06-01       Impact factor: 5.103

3.  APOBEC4 Enhances the Replication of HIV-1.

Authors:  Daniela Marino; Mario Perković; Anika Hain; Ananda A Jaguva Vasudevan; Henning Hofmann; Kay-Martin Hanschmann; Michael D Mühlebach; Gerald G Schumann; Renate König; Klaus Cichutek; Dieter Häussinger; Carsten Münk
Journal:  PLoS One       Date:  2016-06-01       Impact factor: 3.240

4.  Breast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signatures.

Authors:  Kyle J Nakamura; Laura Heath; Edwin R Sobrera; Thomas A Wilkinson; Katherine Semrau; Chipepo Kankasa; Nicole H Tobin; Nicholas E Webb; Benhur Lee; Donald M Thea; Louise Kuhn; James I Mullins; Grace M Aldrovandi
Journal:  Retrovirology       Date:  2017-01-26       Impact factor: 4.602

5.  The HIV-1 transmission bottleneck.

Authors:  Samuel Mundia Kariuki; Philippe Selhorst; Kevin K Ariën; Jeffrey R Dorfman
Journal:  Retrovirology       Date:  2017-03-23       Impact factor: 4.602
  5 in total

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