PURPOSE: Rubella virus (RV) has a central role in the etiopathogenesis of Fuchs' uveitis syndrome (FUS). We aim to offer new insights by comprehensive analysis of recent laboratory and epidemiologic data. METHODS: We conducted a literature search for laboratory data and papers on etiopathogenesis. RESULTS: Aqueous humour samples of FUS patients show immunoreactivity to RV, in a specific and sensitive manner. Identification of RV genome confirm intraocular infection in a subset of FUS patients. Epidemiologic findings further support causality. The clinical spectrum of RV-associated uveitis is similar but not identical to FUS. FUS eyes exhibit a predominance of CD8 + T cells, high IFN-? and IL-10 levels. CONCLUSIONS: RV is the leading cause of FUS. Cytokine-based findings mirror a viral etiology and chronic low-grade inflammation. RV-associated FUS represents a common pathway of intraocular RV inoculation after congenital or acquired infection. Other causes, including HSV and CMV, may lead to FUS.
PURPOSE: Rubella virus (RV) has a central role in the etiopathogenesis of Fuchs' uveitis syndrome (FUS). We aim to offer new insights by comprehensive analysis of recent laboratory and epidemiologic data. METHODS: We conducted a literature search for laboratory data and papers on etiopathogenesis. RESULTS: Aqueous humour samples of FUSpatients show immunoreactivity to RV, in a specific and sensitive manner. Identification of RV genome confirm intraocular infection in a subset of FUSpatients. Epidemiologic findings further support causality. The clinical spectrum of RV-associated uveitis is similar but not identical to FUS. FUS eyes exhibit a predominance of CD8 + T cells, high IFN-? and IL-10 levels. CONCLUSIONS:RV is the leading cause of FUS. Cytokine-based findings mirror a viral etiology and chronic low-grade inflammation. RV-associated FUS represents a common pathway of intraocular RV inoculation after congenital or acquired infection. Other causes, including HSV and CMV, may lead to FUS.
Authors: Ludmila Perelygina; Stanley Plotkin; Pierre Russo; Timo Hautala; Francisco Bonilla; Hans D Ochs; Avni Joshi; John Routes; Kiran Patel; Claudia Wehr; Joseph Icenogle; Kathleen E Sullivan Journal: J Allergy Clin Immunol Date: 2016-09-06 Impact factor: 10.793
Authors: Massimo Accorinti; Giovanni Spinucci; Maria Pia Pirraglia; Simone Bruschi; Francesca Romana Pesci; Ludovico Iannetti Journal: J Ophthalmol Date: 2016-10-03 Impact factor: 1.909
Authors: Ludmila Perelygina; Raeesa Faisthalab; Emily Abernathy; Min-Hsin Chen; LiJuan Hao; Lionel Bercovitch; Diana K Bayer; Lenora M Noroski; Michael T Lam; Maria Pia Cicalese; Waleed Al-Herz; Arti Nanda; Joud Hajjar; Koen Vanden Driessche; Shari Schroven; Julie Leysen; Misha Rosenbach; Philipp Peters; Johannes Raedler; Michael H Albert; Roshini S Abraham; Hemalatha G Rangarjan; David Buchbinder; Lisa Kobrynski; Anne Pham-Huy; Julie Dhossche; Charlotte Cunningham Rundles; Anna K Meyer; Amy Theos; T Prescott Atkinson; Amy Musiek; Mehdi Adeli; Ute Derichs; Christoph Walz; Renate Krüger; Horst von Bernuth; Christoph Klein; Joseph Icenogle; Fabian Hauck; Kathleen E Sullivan Journal: Front Immunol Date: 2021-12-20 Impact factor: 7.561