Antigoni Manousopoulou1, Nasser M Al-Daghri2,3, Spiros D Garbis1,4, George P Chrousos3,5. 1. Clinical and Experimental Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK. 2. Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia. 3. Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, King Saud University, Riyadh, Saudi Arabia. 4. Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK. 5. 1st Department of Pediatrics, University of Athens, Athens, Greece.
Abstract
BACKGROUND: Obesity is a risk factor for both vitamin D deficiency and cardiovascular disease. A link between vitamin D status optimisation and improved cardiometabolic profile among adults with obesity could inform public health initiatives. METHODS: PubMed, Embase and Web of Science were searched for interventional studies examining the effects of vitamin D status improvement on cardiovascular risk factors (anthropometric measures, lipid profile, blood pressure, glucose tolerance) among nondiabetic adults with obesity. RESULTS: Seventeen publications reporting results from 11 different studies were included. Number of participants ranged from 34 to 1179 subjects. Duration was between 6 weeks and 4 years. Vitamin D was administered as a supplement in ten studies (1000 IU daily to 120 000 IU fortnightly). In one study, participants were advised to increase sunlight exposure and dietary vitamin D intake. The random and fixed-effects meta-analysis showed that vitamin D significantly increased systolic blood pressure and LDL-C levels. The fixed-effects model also indicated a significant decrease in triglyceride levels, which was not evident using the random-effects model. Caution should be given to these results given the small number of studies used and the high heterogeneity between studies for the two latter outcomes. Additionally, a subset of eligible studies with compatible data presentation was included in the meta-analysis. CONCLUSION: This systematic review highlights a paucity of interventional studies examining the effects of vitamin D status improvement on cardiovascular risk factors among otherwise healthy adults with obesity. Large-scale studies at pharmacologically relevant doses and with sufficient duration are warranted.
BACKGROUND:Obesity is a risk factor for both vitamin D deficiency and cardiovascular disease. A link between vitamin D status optimisation and improved cardiometabolic profile among adults with obesity could inform public health initiatives. METHODS: PubMed, Embase and Web of Science were searched for interventional studies examining the effects of vitamin D status improvement on cardiovascular risk factors (anthropometric measures, lipid profile, blood pressure, glucose tolerance) among nondiabetic adults with obesity. RESULTS: Seventeen publications reporting results from 11 different studies were included. Number of participants ranged from 34 to 1179 subjects. Duration was between 6 weeks and 4 years. Vitamin D was administered as a supplement in ten studies (1000 IU daily to 120 000 IU fortnightly). In one study, participants were advised to increase sunlight exposure and dietary vitamin D intake. The random and fixed-effects meta-analysis showed that vitamin D significantly increased systolic blood pressure and LDL-C levels. The fixed-effects model also indicated a significant decrease in triglyceride levels, which was not evident using the random-effects model. Caution should be given to these results given the small number of studies used and the high heterogeneity between studies for the two latter outcomes. Additionally, a subset of eligible studies with compatible data presentation was included in the meta-analysis. CONCLUSION: This systematic review highlights a paucity of interventional studies examining the effects of vitamin D status improvement on cardiovascular risk factors among otherwise healthy adults with obesity. Large-scale studies at pharmacologically relevant doses and with sufficient duration are warranted.
Authors: Stefan Pilz; Nicolas Verheyen; Martin R Grübler; Andreas Tomaschitz; Winfried März Journal: Nat Rev Cardiol Date: 2016-05-06 Impact factor: 32.419
Authors: Karin Ma Swart; Paul Lips; Ingeborg A Brouwer; Rolf Jorde; Martijn W Heymans; Guri Grimnes; Martin R Grübler; Martin Gaksch; Andreas Tomaschitz; Stefan Pilz; Gudny Eiriksdottir; Vilmundur Gudnason; Louise Wamberg; Lars Rejnmark; Christopher T Sempos; Ramón A Durazo-Arvizu; Kirsten G Dowling; George Hull; Zuzana Škrabáková; Mairead Kiely; Kevin D Cashman; Natasja M van Schoor Journal: Am J Clin Nutr Date: 2018-06-01 Impact factor: 7.045
Authors: Ali M Alyami; Virginie Lam; Mario J Soares; Yun Zhao; Jillian L Sherriff; John C Mamo; Anthony P James; Fiona Coombes Journal: Nutrients Date: 2016-07-28 Impact factor: 5.717
Authors: Lars Rejnmark; Lise Sofie Bislev; Kevin D Cashman; Gudny Eiríksdottir; Martin Gaksch; Martin Grübler; Guri Grimnes; Vilmundur Gudnason; Paul Lips; Stefan Pilz; Natasja M van Schoor; Mairead Kiely; Rolf Jorde Journal: PLoS One Date: 2017-07-07 Impact factor: 3.240
Authors: Linn A Vikøren; Aslaug Drotningsvik; Marthe T Bergseth; Svein A Mjøs; Nazanin Mola; Sabine Leh; Gunnar Mellgren; Oddrun A Gudbrandsen Journal: Food Nutr Res Date: 2017-06-12 Impact factor: 3.894