Mailton Vasconcelos1, Dirson João Stein2, Rosa Maria M de Almeida1. 1. Instituto de Psicologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. 2. Hospital de Clínicas de Porto Alegre, UFRGS, Porto Alegre, RS, Brazil.
Abstract
INTRODUCTION: Social defeat (SD) in rats, which results from male intraspecific confrontations, is ethologically relevant and useful to understand stress effects on physiology and behavior. METHODS: A systematic review of studies about biomarkers induced by the SD protocol and published from 2002 to 2013 was carried out in the electronic databases PubMed, Web of Knowledge and ScienceDirect. The search terms were: social defeat, rat, neurotrophins, neuroinflammatory markers, and transcriptional factors. RESULTS: Classical and recently discovered biomarkers were found to be relevant in stress-induced states. Findings were summarized in accordance to the length of exposure to stress: single, repeated, intermittent and continuous SD. This review found that the brain-derived neurotrophic factor (BDNF) is a distinct marker of stress adaptation. Along with glucocorticoids and catecholamines, BDNF seems to be important in understanding stress physiology. CONCLUSION: The SD model provides a relevant tool to study stress response features, development of addictive behaviors, clinic depression and anxiety, as well as individual differences in vulnerability and resilience to stress.
INTRODUCTION: Social defeat (SD) in rats, which results from male intraspecific confrontations, is ethologically relevant and useful to understand stress effects on physiology and behavior. METHODS: A systematic review of studies about biomarkers induced by the SD protocol and published from 2002 to 2013 was carried out in the electronic databases PubMed, Web of Knowledge and ScienceDirect. The search terms were: social defeat, rat, neurotrophins, neuroinflammatory markers, and transcriptional factors. RESULTS: Classical and recently discovered biomarkers were found to be relevant in stress-induced states. Findings were summarized in accordance to the length of exposure to stress: single, repeated, intermittent and continuous SD. This review found that the brain-derived neurotrophic factor (BDNF) is a distinct marker of stress adaptation. Along with glucocorticoids and catecholamines, BDNF seems to be important in understanding stress physiology. CONCLUSION: The SD model provides a relevant tool to study stress response features, development of addictive behaviors, clinic depression and anxiety, as well as individual differences in vulnerability and resilience to stress.
Authors: Mailton Vasconcelos; Dirson J Stein; Lucas Albrechet-Souza; Klaus A Miczek; Rosa Maria M de Almeida Journal: Behav Brain Res Date: 2018-01-09 Impact factor: 3.332
Authors: Vipin Arora; Thomas J Martin; Carol A Aschenbrenner; Kenichiro Hayashida; Susy A Kim; Renee A Parker; James C Eisenach; Christopher M Peters Journal: Neuroscience Date: 2018-04-22 Impact factor: 3.590
Authors: Gopalkumar Rakesh; Rajendra A Morey; Anthony S Zannas; Zainab Malik; Christine E Marx; Ashley N Clausen; Michael D Kritzer; Steven T Szabo Journal: Mol Psychiatry Date: 2019-03-13 Impact factor: 15.992
Authors: Dirson J Stein; Mailton F Vasconcelos; Lucas Albrechet-Souza; Keila M M Ceresér; Rosa M M de Almeida Journal: Front Behav Neurosci Date: 2017-10-24 Impact factor: 3.558
Authors: Carmine M Pariante; Cathy Fernandes; Andrea Du Preez; Thomas Law; Diletta Onorato; Yau M Lim; Paola Eiben; Ksenia Musaelyan; Martin Egeland; Abdul Hye; Patricia A Zunszain; Sandrine Thuret Journal: Transl Psychiatry Date: 2020-09-21 Impact factor: 6.222