Clinical perspectives on mesenchymal stem cells promoting wound healing in diabetes mellitus patients by inducing autophagy.

BACKGROUND: The pathogenesis of wound healing in diabetes mellitus is complicated, and results in less effective healing. Mesenchymal stem cells (MSCs) have been thought to promote wound healing in diabetes. However, the underlying mechanisms are not well understood. Autophagy plays an important role in wound healing. It has been speculated that the mesenchymal stem cells derived from the umbilical cord can improve wound healing in diabetes mellitus by inducing autophagy. Hence, we reviewed the research progress in this field to identify new strategies of clinical treatment for wound healing in diabetes mellitus.