Feng Zhou1, Zhida Qian2, Yinghua Li2, Jiale Qin3, Lili Huang2. 1. Department of Pathology, Women's Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, China. 2. Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, China. 3. Department of Ultrasound, Women's Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, China.
Abstract
OBJECTIVES: To report two extremely rare cases of endometrial adenocarcinoma established during the first trimester. CASE PRESENTATION: A 40-year-old (gravida 0, para 0) and 33-year-old (gravida 4, para 0) woman, were diagnosed with a well-differentiated adenocarcinoma after a dilatation and curettage (D&C) for spontaneous abortions at 8 and 9 gestational weeks, respectively. CONCLUSIONS: Thirty-six cases of pregnancy-associated endometrial cancer and 20 cases of first trimester pregnancy concurrent with endometrial carcinoma have been reported as present cases in the literature. Interestingly, 15 including our two cases were detected for spontaneous abortions in first-trimester suggesting a causal correlation between endometrial adenocarcinoma and spontaneous abortions. Repeated D&C and progesterone administration may be appropriate for patients who wish to preserve fertility.
OBJECTIVES: To report two extremely rare cases of endometrial adenocarcinoma established during the first trimester. CASE PRESENTATION: A 40-year-old (gravida 0, para 0) and 33-year-old (gravida 4, para 0) woman, were diagnosed with a well-differentiated adenocarcinoma after a dilatation and curettage (D&C) for spontaneous abortions at 8 and 9 gestational weeks, respectively. CONCLUSIONS: Thirty-six cases of pregnancy-associated endometrial cancer and 20 cases of first trimester pregnancy concurrent with endometrial carcinoma have been reported as present cases in the literature. Interestingly, 15 including our two cases were detected for spontaneous abortions in first-trimester suggesting a causal correlation between endometrial adenocarcinoma and spontaneous abortions. Repeated D&C and progesterone administration may be appropriate for patients who wish to preserve fertility.
Entities:
Keywords:
Endometrial adenocarcinoma; early pregnancy; spontaneous abortions
Authors: Agnieszka K Witkiewicz; Thomas McConnell; Magdalena Potoczek; Robert V B Emmons; Robert J Kurman Journal: Hum Pathol Date: 2009-09-04 Impact factor: 3.466