Serkan Bodur1, Ozgur Dundar2, Mine Kanat Pektas3, Mustafa Alparslan Babayigit4, Okan Ozden1, Zafer Kucukodacı5. 1. Department of Obstetrics, Gulhane Military Medical Academy, Gynecology and Reproductive Sciences Ankara, Turkey. 2. Department of Obstetrics and Gynecology, GATA Haydarpasa Military Education Hospital Istanbul, Turkey. 3. Department of Obstetrics and Gynecology, Afyon Kocatepe University Medical Faculty Hospital Afyon, Turkey. 4. Department of Public and Environmental Health, Gülhane Military Medical Academy Ankara, Turkey. 5. Department of Pathology, GATA Haydarpasa Military Education Hospital Istanbul, Turkey.
Abstract
OBJECTIVE: The present study aims to analyze the diagnostic accuracy of clinical characteristics together with new emerging laboratory markers of adenomyosis. METHODS: This study was a retrospective analysis of clinical and laboratory characteristics of 99 women who underwent hysterectomies with (study group) or without (control group) a diagnosis of adenomyosis, 56 and 43 patients in each group, respectively. RESULTS: The women with adenomyosis were more likely to have younger age (OR = 1.14, 0.789-0.971 95% CI, P = 0.010), higher parity (OR = 1.81, 0.308-0.988 95% CI, P = 0.046), higher number of curettage (OR = 1.90, 1.189-3.041 95% CI, P = 0.007), dysmenorrhea (OR = 117.49, 2.715-5084.883 95% CI, P = 0.013) and elevated mean platelet volume (OR = 5.17, 2.054-13.028 95% CI, P = 0.000). After receiver-operating-characteristics curve analysis, using a cut-point of 8.5 fL, the preoperative mean platelet volume predicted adenomyosis with a sensitivity of 56.6% and specificity of 82.6%. CONCLUSIONS: Those findings suggest gynecologists to give priority on adenomyosis when premenopausal paraous patient with a history of curettages admitted with a complaint of dysmenorrhea and elevated levels of MPV.
OBJECTIVE: The present study aims to analyze the diagnostic accuracy of clinical characteristics together with new emerging laboratory markers of adenomyosis. METHODS: This study was a retrospective analysis of clinical and laboratory characteristics of 99 women who underwent hysterectomies with (study group) or without (control group) a diagnosis of adenomyosis, 56 and 43 patients in each group, respectively. RESULTS: The women with adenomyosis were more likely to have younger age (OR = 1.14, 0.789-0.971 95% CI, P = 0.010), higher parity (OR = 1.81, 0.308-0.988 95% CI, P = 0.046), higher number of curettage (OR = 1.90, 1.189-3.041 95% CI, P = 0.007), dysmenorrhea (OR = 117.49, 2.715-5084.883 95% CI, P = 0.013) and elevated mean platelet volume (OR = 5.17, 2.054-13.028 95% CI, P = 0.000). After receiver-operating-characteristics curve analysis, using a cut-point of 8.5 fL, the preoperative mean platelet volume predicted adenomyosis with a sensitivity of 56.6% and specificity of 82.6%. CONCLUSIONS: Those findings suggest gynecologists to give priority on adenomyosis when premenopausal paraous patient with a history of curettages admitted with a complaint of dysmenorrhea and elevated levels of MPV.
Entities:
Keywords:
Adenomyosis; dysmenorrhea; mean platelet volume
Authors: H Koike; H Egawa; T Ohtsuka; M Yamaguchi; T Ikenoue; N Mori Journal: Prostaglandins Leukot Essent Fatty Acids Date: 1992-06 Impact factor: 4.006