BACKGROUND: A large body of studies has investigated the potential role of ABCB1 polymorphism in ALL susceptibility. However, the results are conflicting. The aim of the present meta-analysis was to define the effect of ABCB1 polymorphism on ALL risk. METHODS: We identified 8 eligible studies involving 1,308 cases and 1,427 controls through searching PubMed and Enbase databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to access the strength of the association with both fixed effects and random effect models. RESULTS: We found ABCB1 polymorphism was associated with an increased risk of ALL under the homozygote genotypes (TT vs. CC: OR, 1.29, 95% CI, 1.08-1.54), the recessive model (TT vs. CT + CC: OR, 1.47, 95% CI, 1.02-2.13) and the allele model (T vs. C: OR, 1.14, 95% CI, 1.04-1.25). Similar results were indicated in Asian populations (TT vs. CC: OR, 1.79, 95% CI, 1.32-2.43; TT vs. CT + CC: OR, 2.55, 95% CI, 1.47-4.43; T vs. C: OR, 1.38, 95% CI, 1.18-1.62), but not in Caucasian populations. CONCLUSIONS: These findings indicate that ABCB1 polymorphism may play a critical role in the development of ALL in Asians.
BACKGROUND: A large body of studies has investigated the potential role of ABCB1 polymorphism in ALL susceptibility. However, the results are conflicting. The aim of the present meta-analysis was to define the effect of ABCB1 polymorphism on ALL risk. METHODS: We identified 8 eligible studies involving 1,308 cases and 1,427 controls through searching PubMed and Enbase databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to access the strength of the association with both fixed effects and random effect models. RESULTS: We found ABCB1 polymorphism was associated with an increased risk of ALL under the homozygote genotypes (TT vs. CC: OR, 1.29, 95% CI, 1.08-1.54), the recessive model (TT vs. CT + CC: OR, 1.47, 95% CI, 1.02-2.13) and the allele model (T vs. C: OR, 1.14, 95% CI, 1.04-1.25). Similar results were indicated in Asian populations (TT vs. CC: OR, 1.79, 95% CI, 1.32-2.43; TT vs. CT + CC: OR, 2.55, 95% CI, 1.47-4.43; T vs. C: OR, 1.38, 95% CI, 1.18-1.62), but not in Caucasian populations. CONCLUSIONS: These findings indicate that ABCB1 polymorphism may play a critical role in the development of ALL in Asians.
Authors: Evelia Leal-Ugarte; Melva Gutiérrez-Angulo; Nelly M Macías-Gómez; Valeria Peralta-Leal; Jorge Durán-González; María De La Luz Ayala-Madrigal; Miriam Partida-Pérez; Patricio Barros-Núñez; Dinorah Ruiz-Díaz; José M Moreno-Ortiz; Jorge Peregrina-Sandoval; Juan Pablo Meza-Espinoza Journal: Hum Biol Date: 2008-08 Impact factor: 0.553
Authors: Kevin Y Urayama; John K Wiencke; Patricia A Buffler; Anand P Chokkalingam; Catherine Metayer; Joseph L Wiemels Journal: Cancer Epidemiol Biomarkers Prev Date: 2007-06 Impact factor: 4.254
Authors: Andrés López-Cortés; Santiago Guerrero; María Ana Redal; Angel Tito Alvarado; Luis Abel Quiñones Journal: Int J Mol Sci Date: 2017-05-23 Impact factor: 5.923