Manal Ea Elhalwagy1, Sherif H Abd-Alrahman2, A A Nahas3, Reem M Ziada3, Aziza H Mohamady4. 1. Department of Biochemistry, Faculty of Science for Girls, King Abdulaziz University P.O Box, 51459, Jeddah, 21453, KSA. 2. Biochemistry Department, College of Science, King Saud University PO Box, 2455, Riyadh 11451, Saudi Arabia ; Department of Pesticide Residue and Environmental Pollution, Pesticide Central Laboratory, Agriculture Research Center Giza 12618, Egypt. 3. Department of Mammalian Toxicology, Pesticide Central Laboratory, Agriculture Research Center Giza 12618, Egypt. 4. Bioassay Department, Pesticide Central Laboratory, Agriculture Research Center Giza 12618, Egypt ; Chemistry Department, Faculty of Science, Hail University Hail, Kingdom of Saudi Arabia.
Abstract
BACKGROUND: Despite the known adverse effects of lambda cyhalothrin insecticide, little is known about its hepatopancreatic intoxication effects. The present study was carried out to elucidate sub-chronic effect of Karat 2.5% EC formulation of lambda cyhalothrin on male albino rats. METHODS: To explore the effects of exposure to lambda cyhalothrin on rats and its mechanism, low (1/40 of LD50, 5 mg/kg/day) and high dose (1/4 of LD50, 50 mg/kg/day) lambda cyhalothrin were applied to rats via drinking water for 3 months. Blood samples were collected monthly, and the animals were dissected for liver and pancreas's examination at the end of the experiment. Lambda cyhalothrin administration was associated with the elevation in lipid peroxidation marker, malondialdehyde (MDA), reduction in SH-protein a major marker for antioxidant, as well as basel paraoxonase (PON) in both treated groups throughout the experimental periods. RESULTS: In addition, significant elevations in liver enzymes alanin amino transferase, (ALT), and aspartate amino transferase (AST), as well as plasma acetylcholinesterase (AChE) and glucose level. While, significant reduction in insulin level through the experimental periods. Results of histopathological and histochemical studies showed that lambda cyhalothrin exposure induces liver and pancreatic tissues damage and depletion in glycogen content was pronounced in liver of both treated groups. CONCLUSIONS: In conclusion subchronic intoxication with lambda cyhalothrin formulation induced remarkable changes in the examined parameters.
BACKGROUND: Despite the known adverse effects of lambda cyhalothrin insecticide, little is known about its hepatopancreatic intoxication effects. The present study was carried out to elucidate sub-chronic effect of Karat 2.5% EC formulation of lambda cyhalothrin on male albino rats. METHODS: To explore the effects of exposure to lambda cyhalothrin on rats and its mechanism, low (1/40 of LD50, 5 mg/kg/day) and high dose (1/4 of LD50, 50 mg/kg/day) lambda cyhalothrin were applied to rats via drinking water for 3 months. Blood samples were collected monthly, and the animals were dissected for liver and pancreas's examination at the end of the experiment. Lambda cyhalothrin administration was associated with the elevation in lipid peroxidation marker, malondialdehyde (MDA), reduction in SH-protein a major marker for antioxidant, as well as basel paraoxonase (PON) in both treated groups throughout the experimental periods. RESULTS: In addition, significant elevations in liver enzymes alanin amino transferase, (ALT), and aspartate amino transferase (AST), as well as plasma acetylcholinesterase (AChE) and glucose level. While, significant reduction in insulin level through the experimental periods. Results of histopathological and histochemical studies showed that lambda cyhalothrin exposure induces liver and pancreatic tissues damage and depletion in glycogen content was pronounced in liver of both treated groups. CONCLUSIONS: In conclusion subchronic intoxication with lambda cyhalothrin formulation induced remarkable changes in the examined parameters.
Authors: Duk-Hee Lee; In-Kyu Lee; Kyungeun Song; Michael Steffes; William Toscano; Beth A Baker; David R Jacobs Journal: Diabetes Care Date: 2006-07 Impact factor: 19.112
Authors: Tajamul Hussain; Nasser M Al-Daghri; Omar S Al-Attas; Hossam M Draz; Sherif H Abd Al-Rahman; Sobhy M Yakout Journal: Regul Pept Date: 2012-02-28
Authors: Rachel L Miller; Robin Garfinkel; Megan Horton; David Camann; Frederica P Perera; Robin M Whyatt; Patrick L Kinney Journal: Chest Date: 2004-10 Impact factor: 9.410
Authors: Zheng Li; Courtney D Sandau; Lovisa C Romanoff; Samuel P Caudill; Andreas Sjodin; Larry L Needham; Donald G Patterson Journal: Environ Res Date: 2008-03-03 Impact factor: 6.498