Literature DB >> 26221231

The 5-hydroxytryptamine transporter is functional in human coronary artery smooth muscle cells proliferation and is regulated by Interleukin-1 beta.

Qing-Jie Wang1, Dong Wang1, Cheng-Chun Tang1.   

Abstract

Abnormal human coronary artery smooth muscle cells (hCASMCs) proliferation and migration are key factors in coronary artery restenosis after percutaneous coronary intervention. Platelets release 5-hydroxytryptamine (5-HT), which is a strong mitogen for pulmonary artery smooth muscle cells proliferation and migration. Here, we investigated the effects of 5-HT and role of 5-HT transporter (5-HTT) on hCASMCs proliferation and migration. The 5-HT (10(-6)-10(-5) mol/l) significantly increased hCASMCs proliferation and migration, and these effects were inhibited by fluoxetine (10(-5) mol/l) and citalopram (10(-6) mol/l), two 5-HTT blocker. Overexpression in hCASMCs enhanced 5-HT induced cells proliferation and migration. The 5-HTT and interleukin-1 beta (IL-1β) expression were increased in rat balloon injury carotid arteries. Treatment with IL-1β (10 ng/ml, 3d) upregulates 5-HTT expression in hCASMCs and increased 5-HT induced currents in Human Embryonic Kidney 293-5-HTT cells.

Entities:  

Keywords:  5-hydroxytryptamine transporter; Human coronary artery smooth muscle cells; interleukin-1 beta

Year:  2015        PMID： 26221231      PMCID： PMC4509176     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  23 in total

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Review 2.  Migration of smooth muscle and endothelial cells. Critical events in restenosis.

Authors:  W Casscells
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3.  Temporal and spatial distribution of interleukin-1 beta in balloon injured porcine coronary arteries.

Authors:  J Chamberlain; J Gunn; S Francis; C Holt; D Crossman
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Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

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