Yue Wang1, Hong Duan2, Helen Yang3, Jie Lin1. 1. Deaprtment of Surgery, Liaoning Cancer Hospital and Institute Shenyang, China. 2. Department of Epidemiology, Zhengzhou University Zhengzhou, China. 3. Institute of Public Health, University of California San Francisco, USA.
Abstract
OBJECT: In order to provide an updated quantification of the association between alcohol intake and colorectal cancer, we conducted a meta-analysis of published observational studies. METHOD: Two cohort and 22 case-control studies presenting results for at least three categories of alcohol intake were identified from a PubMed search of articles published before July 2014. Data were extracted independently by two reviewers. Random effects meta-analyses, subgroup analyses, and meta regression were performed for modeling the dose-response relation. RESULT: The pooled relative risk (RR) for any alcohol intake compared with non/occasional drinking was 1.13 [95% confidence interval (CI), 1.09-1.17]. The RRs were 1.07 (95% CI, 1.02-1.13), 1.23 (95% CI, 1.15-1.32) and 1.37 (95% CI, 1.26-1.49) for light (≤12.5 g/day), moderate (12.6 to 49.9 g/day) and heavy drinking (≥50 g/day), respectively. The risks were consistent in the subgroup analyses of sex and tumor site. CONCLUSION: This meta-analysis provides strong evidence for an association between alcohol intake and colorectal cancer risk.
OBJECT: In order to provide an updated quantification of the association between alcohol intake and colorectal cancer, we conducted a meta-analysis of published observational studies. METHOD: Two cohort and 22 case-control studies presenting results for at least three categories of alcohol intake were identified from a PubMed search of articles published before July 2014. Data were extracted independently by two reviewers. Random effects meta-analyses, subgroup analyses, and meta regression were performed for modeling the dose-response relation. RESULT: The pooled relative risk (RR) for any alcohol intake compared with non/occasional drinking was 1.13 [95% confidence interval (CI), 1.09-1.17]. The RRs were 1.07 (95% CI, 1.02-1.13), 1.23 (95% CI, 1.15-1.32) and 1.37 (95% CI, 1.26-1.49) for light (≤12.5 g/day), moderate (12.6 to 49.9 g/day) and heavy drinking (≥50 g/day), respectively. The risks were consistent in the subgroup analyses of sex and tumor site. CONCLUSION: This meta-analysis provides strong evidence for an association between alcohol intake and colorectal cancer risk.
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