Elaine Fuertes1, Johannes Bracher2, Claudia Flexeder3, Iana Markevych4, Claudia Klümper5, Barbara Hoffmann6, Ursula Krämer7, Andrea von Berg8, Carl-Peter Bauer9, Sibylle Koletzko10, Dietrich Berdel11, Joachim Heinrich12, Holger Schulz13. 1. Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. Electronic address: elaine.fuertes@helmholtz-muenchen.de. 2. Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. Electronic address: johannes.bracher@helmholtz-muenchen.de. 3. Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. Electronic address: claudia.flexeder@helmholtz-muenchen.de. 4. Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany; Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig Maximilians University of Munich, Lindwurmstraße 4, 80337 Munich, Germany. Electronic address: iana.markevych@helmholtz-muenchen.de. 5. IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany. Electronic address: Claudia.Kluemper@IUF-Duesseldorf.de. 6. IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany; Heinrich-Heine University of Düsseldorf, Medical Faculty, Deanery of Medicine, 40204 Düsseldorf, Germany. Electronic address: B.Hoffmann@uni-duesseldorf.de. 7. IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany. Electronic address: Ursula.Kraemer@IUF-Duesseldorf.de. 8. Research Institute, Department of Pediatrics, Marien-Hospital Wesel, Pastor-Janßen-Str. 8-38, 46483 Wesel, Germany. Electronic address: avb.rodehorst@gmx.de. 9. Department of Pediatrics, Technical University of Munich, Geschwister-Scholl-Platz 1, 80539 Munich, Germany. Electronic address: cpbauer@t-online.de. 10. Division of Paediatric Gastroenterology and Hepatology, Ludwig Maximilians University of Munich, Dr. von Hauner Children's Hospital, Lindwurmstraße 4, 80337 Munich, Germany. Electronic address: Sibylle.Koletzko@med.uni-muenchen.de. 11. Research Institute, Department of Pediatrics, Marien-Hospital Wesel, Pastor-Janßen-Str. 8-38, 46483 Wesel, Germany. Electronic address: berdel.vonberg@t-online.de. 12. Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Max-Lebsche-Platz 31, 81377 Munich, Germany. Electronic address: heinrich@helmholtz-muenchen.de. 13. Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Max-Lebsche-Platz 31, 81377 Munich, Germany. Electronic address: schulz@helmholtz-muenchen.de.
Abstract
INTRODUCTION: The impact of outdoor air pollution exposure on long-term lung development and potential periods of increased lung susceptibility remain unknown. This study assessed associations between early-life and current residential exposure to air pollution and lung function at 15-years of age in two German birth cohorts. METHODS: Fifteen year-old participants living in an urban and rural area in Germany underwent spirometry before and after bronchodilation (N=2266). Annual average (long-term) exposure to nitrogen dioxide (NO(2)), particles with aerodynamic diameters less than 2.5 μg/m(3) (PM2.5) mass and less than 10 μg/m(3) (PM(10)) mass, PM(2.5) absorbance and ozone were estimated to each participant's birth-, 10- and 15-year home address using land-use regression and kriging (ozone only) modelling. Associations between lung function variables and long-term pollutant concentrations were assessed using linear regression models adjusted for host and environmental covariates and recent short-term air pollution exposures. RESULTS: Long-term air pollution concentrations assessed to the birth-, 10- and 15-year home addresses were not associated with lung function variables, before and after bronchodilation, in the complete or study area specific populations. However, several lung function variables were negatively associated with long-term NO2 concentrations among asthmatics. For example, NO(2) estimated to the 15-year home address was associated with the ratio of forced expiratory volume in one second to forced vital capacity (FEV(1)/FVC) and the mean flow rate between 25% and 75% of FVC (-3.5%, 95% confidence interval [-6.0, -1.0] and -297.4 ml/s [-592.6, -2.1] per 5.9 μg/m(3) increase in NO(2), respectively). Nearly all effect estimates for the associations between the short-term PM(2.5) mass, PM(10) mass and ozone concentrations and the lung function variables were negative in the complete population. CONCLUSIONS: Early-life and current long-term air pollution exposures and lung function at the age of 15 years were not associated in the complete study population. Asthmatics may represent a vulnerable group.
INTRODUCTION: The impact of outdoor air pollution exposure on long-term lung development and potential periods of increased lung susceptibility remain unknown. This study assessed associations between early-life and current residential exposure to air pollution and lung function at 15-years of age in two German birth cohorts. METHODS: Fifteen year-old participants living in an urban and rural area in Germany underwent spirometry before and after bronchodilation (N=2266). Annual average (long-term) exposure to nitrogen dioxide (NO(2)), particles with aerodynamic diameters less than 2.5 μg/m(3) (PM2.5) mass and less than 10 μg/m(3) (PM(10)) mass, PM(2.5) absorbance and ozone were estimated to each participant's birth-, 10- and 15-year home address using land-use regression and kriging (ozone only) modelling. Associations between lung function variables and long-term pollutant concentrations were assessed using linear regression models adjusted for host and environmental covariates and recent short-term air pollution exposures. RESULTS: Long-term air pollution concentrations assessed to the birth-, 10- and 15-year home addresses were not associated with lung function variables, before and after bronchodilation, in the complete or study area specific populations. However, several lung function variables were negatively associated with long-term NO2 concentrations among asthmatics. For example, NO(2) estimated to the 15-year home address was associated with the ratio of forced expiratory volume in one second to forced vital capacity (FEV(1)/FVC) and the mean flow rate between 25% and 75% of FVC (-3.5%, 95% confidence interval [-6.0, -1.0] and -297.4 ml/s [-592.6, -2.1] per 5.9 μg/m(3) increase in NO(2), respectively). Nearly all effect estimates for the associations between the short-term PM(2.5) mass, PM(10) mass and ozone concentrations and the lung function variables were negative in the complete population. CONCLUSIONS: Early-life and current long-term air pollution exposures and lung function at the age of 15 years were not associated in the complete study population. Asthmatics may represent a vulnerable group.
Authors: Agnes Luzak; Elaine Fuertes; Claudia Flexeder; Marie Standl; Andrea von Berg; Dietrich Berdel; Sibylle Koletzko; Joachim Heinrich; Dennis Nowak; Holger Schulz Journal: Respir Res Date: 2017-07-12
Authors: John Gulliver; Paul Elliott; John Henderson; Anna L Hansell; Danielle Vienneau; Yutong Cai; Adrienne McCrea; Kevin Garwood; Andy Boyd; Lucy Neal; Paul Agnew; Daniela Fecht; David Briggs; Kees de Hoogh Journal: Environ Int Date: 2018-01-28 Impact factor: 9.621
Authors: Yutong Cai; Anna L Hansell; Raquel Granell; Marta Blangiardo; Mariagrazia Zottoli; Daniela Fecht; John Gulliver; A John Henderson; Paul Elliott Journal: Am J Respir Crit Care Med Date: 2020-07-01 Impact factor: 21.405