Jodie G Katon1, Kristen E Gray2, Megan R Gerber3, Laura B Harrington4, Nancy F Woods5, Julie C Weitlauf6, Bevanne Bean-Mayberry7, Karen M Goldstein8, Julie R Hunt9, Wayne J Katon10, Sally G Haskell11, Susan J McCutcheon12, Margery L Gass13, Carolyn J Gibson14, Laurie C Zephyrin15. 1. Health Services Research and Development (HSR&D), VA Puget Sound Health Care System, Seattle, Washington. Women's Health Services, VA Office of Patient Care, Washington, District of Columbia. jodie.katon@va.gov. 2. Health Services Research and Development (HSR&D), VA Puget Sound Health Care System, Seattle, Washington. Department of Health Services, University of Washington School of Public Health, Seattle. 3. VA Boston Healthcare System, Boston, Massachusetts. 4. Department of Epidemiology, University of Washington School of Public Health, Seattle. 5. University of Washington School of Nursing, Seattle. 6. VA Palo Alto Health Care System, California. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California. 7. VA HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy, VA Greater Los Angeles Health Care System, California. Division of General Internal Medicine, VA Greater Los Angeles Health Care System, California. 8. Durham VA Medical Center, North Carolina. Department of General Internal Medicine, Duke University School of Medicine, Durham, North Carolina. 9. Fred Hutchinson Cancer Research Center, Seattle, Washington. 10. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle. 11. Women's Health Services, VA Office of Patient Care, Washington, District of Columbia. VA Connecticut Health Care System, New Haven. 12. Women's Health Services, VA Office of Patient Care, Washington, District of Columbia. 13. Cleveland Clinic Lerner College of Medicine Case Western Reserve University, Mayfield Heights, Ohio. 14. Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington. 15. Women's Health Services, VA Office of Patient Care, Washington, District of Columbia. Department of Obstetrics and Gynecology, New York University Langone School of Medicine.
Abstract
INTRODUCTION: Vasomotor symptoms (VMS), including hot flashes and night sweats, are common among postmenopausal women and are associated with reduced health related quality of life (HRQOL). PURPOSE OF THE STUDY: To determine whether Veterans are more likely to report VMS than non-Veterans, and whether the association of VMS with HRQOL varies by Veteran status. DESIGN AND METHODS: We used data from the Women's Health Initiative Observational Study, including self-reported baseline VMS presence and severity, and HRQOL at follow-up Year 3 (RAND Short Form 36-Item Health Survey). Employing generalized linear models we estimated whether Veteran status was associated with any VMS. We estimated the association between any VMS and HRQOL using linear regression, stratified by Veteran status. Interaction terms were added separately to determine whether the association varied by baseline depression, obesity, or smoking status. RESULTS: The final analyses included 77,153 postmenopausal women (2,004 Veterans). After adjustment, Veterans were no more likely than non-Veterans to report any VMS at baseline (relative risk [RR] 0.97, 95% confidence interval [CI] 0.90-1.04) or moderate to severe VMS (RR 1.03, 95% CI 0.89-1.18). Any VMS was associated with decreased HRQOL at Year 3, particularly among Veterans (mean difference range: Veterans -2.7 to -4.6, p-values < .001; non-Veterans -2.2 to -2.6, 95% CI -0.13 to -0.09, p values < .001). Baseline depression and obesity, but not smoking, amplified the negative association between VMS and HRQOL. IMPLICATIONS: Multicondition care models for postmenopausal Veteran and non-Veteran women are needed that incorporate management strategies for VMS, weight, and depression. Published by Oxford University Press on behalf of the Gerontological Society of America 2015.
INTRODUCTION: Vasomotor symptoms (VMS), including hot flashes and night sweats, are common among postmenopausal women and are associated with reduced health related quality of life (HRQOL). PURPOSE OF THE STUDY: To determine whether Veterans are more likely to report VMS than non-Veterans, and whether the association of VMS with HRQOL varies by Veteran status. DESIGN AND METHODS: We used data from the Women's Health Initiative Observational Study, including self-reported baseline VMS presence and severity, and HRQOL at follow-up Year 3 (RAND Short Form 36-Item Health Survey). Employing generalized linear models we estimated whether Veteran status was associated with any VMS. We estimated the association between any VMS and HRQOL using linear regression, stratified by Veteran status. Interaction terms were added separately to determine whether the association varied by baseline depression, obesity, or smoking status. RESULTS: The final analyses included 77,153 postmenopausal women (2,004 Veterans). After adjustment, Veterans were no more likely than non-Veterans to report any VMS at baseline (relative risk [RR] 0.97, 95% confidence interval [CI] 0.90-1.04) or moderate to severe VMS (RR 1.03, 95% CI 0.89-1.18). Any VMS was associated with decreased HRQOL at Year 3, particularly among Veterans (mean difference range: Veterans -2.7 to -4.6, p-values < .001; non-Veterans -2.2 to -2.6, 95% CI -0.13 to -0.09, p values < .001). Baseline depression and obesity, but not smoking, amplified the negative association between VMS and HRQOL. IMPLICATIONS: Multicondition care models for postmenopausal Veteran and non-Veteran women are needed that incorporate management strategies for VMS, weight, and depression. Published by Oxford University Press on behalf of the Gerontological Society of America 2015.
Entities:
Keywords:
Depression; Obesity; Quality of life; Vasomotor symptoms; Veterans
Authors: Jodie G Katon; Laurie Zephyrin; Anne Meoli; Avanthi Hulugalle; Jeane Bosch; Lisa Callegari; Ileana V Galvan; Kristen E Gray; Kristin O Haeger; Claire Hoffmire; Silvina Levis; Erica W Ma; Jennifer E Mccabe; Yael I Nillni; Suzanne L Pineles; Shivani M Reddy; David A Savitz; Jonathan G Shaw; Elizabeth W Patton Journal: Semin Reprod Med Date: 2019-04-19 Impact factor: 1.303
Authors: Claire A Hoffmire; Lisa A Brenner; Jodie Katon; Laurel A Gaeddert; Christin N Miller; Alexandra L Schneider; Lindsey L Monteith Journal: Womens Health Issues Date: 2022-03-08
Authors: Karen M Goldstein; Jennifer R McDuffie; Megan Shepherd-Banigan; Deanna Befus; Remy R Coeytaux; Megan G Van Noord; Adam P Goode; Varsha Masilamani; Soheir Adam; Avishek Nagi; John W Williams Journal: Syst Rev Date: 2016-04-07