D M Hanshaw1, J W Finnie2,3, J Manavis4, A E Kessell1. 1. Gribbles Veterinary Pathology (VETLAB), Adelaide, SA, Australia. 2. SA Pathology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia. john.finnie@health.sa.gov.au. 3. School of Veterinary Science, University of Adelaide, Adelaide, SA, Australia. john.finnie@health.sa.gov.au. 4. SA Pathology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia.
Abstract
CASE REPORT: An 18-month-old Angus cow presented with rapidly developing ataxia and subsequently died. The finding of large numbers of axonal spheroids in brainstem nuclei and spinal cord grey matter, bilaterally symmetrical in distribution, was consistent with a histopathological diagnosis of neuroaxonal dystrophy (NAD). Most of the axonal swellings were immunopositive to amyloid precursor protein, suggesting that interruption to axonal flow was important in their genesis. CONCLUSIONS: The topographical distribution of axonal spheroids in the brain and spinal cord in this bovine case closely resembled that found in the ovine neurodegenerative disorder termed NAD, in which axonal swellings are the major pathological feature. This appears to be the first reported case of this type of NAD in cattle. The aetiology of the spheroidal aggregations in this case was not determined. There was no evidence from the case history or neuropathology to indicate whether the axonal spheroids in this case involved an acquired or heritable aetiology.
CASE REPORT: An 18-month-old Angus cow presented with rapidly developing ataxia and subsequently died. The finding of large numbers of axonal spheroids in brainstem nuclei and spinal cord grey matter, bilaterally symmetrical in distribution, was consistent with a histopathological diagnosis of neuroaxonal dystrophy (NAD). Most of the axonal swellings were immunopositive to amyloid precursor protein, suggesting that interruption to axonal flow was important in their genesis. CONCLUSIONS: The topographical distribution of axonal spheroids in the brain and spinal cord in this bovine case closely resembled that found in the ovine neurodegenerative disorder termed NAD, in which axonal swellings are the major pathological feature. This appears to be the first reported case of this type of NAD in cattle. The aetiology of the spheroidal aggregations in this case was not determined. There was no evidence from the case history or neuropathology to indicate whether the axonal spheroids in this case involved an acquired or heritable aetiology.
Authors: Katherine L Lucot; Peter J Dickinson; Carrie J Finno; Tamer A Mansour; Anna Letko; Katherine M Minor; James R Mickelson; Cord Drögemüller; C Titus Brown; Danika L Bannasch Journal: G3 (Bethesda) Date: 2018-07-31 Impact factor: 3.154