Paolo Bucciarelli1, Alberto Maino2, Irene Felicetta3, Maria Abbattista2, Serena M Passamonti2, Andrea Artoni2, Ida Martinelli2. 1. Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: bucciarelli@policlinico.mi.it. 2. Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy. 3. Laboratorio di Chimica Clinica, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
Abstract
BACKGROUND: An association between high red cell distribution width (RDW) and venous thromboembolism (VTE) has been observed. However, it is not known whether this association differs within various manifestations of VTE, nor if there is an interaction between RDW and thrombophilia abnormalities on the risk of VTE. AIMS: To investigate whether RDW is a marker of the risk of VTE; to identify subgroups of patients in which the association between RDW and VTE is stronger; to investigate a possible interaction between RDW and thrombophilia abnormalities. METHODS: Case-control study on 730 patients with a first objectively-confirmed VTE episode (300 unprovoked and 430 provoked) consecutively referred to our Center between 2007 and 2013, and 352 healthy controls. Blood was taken for a thrombophilia work-up and a complete blood count, including RDW, at least three months after VTE. RESULTS: Individuals with RDW above the 90(th) percentile (>14.6%) had a 2.5-fold increased risk of VTE compared to those with RDW ≤90(th) percentile, independently of age, sex, body mass index, other hematological variables and renal function (adjusted odds ratio: 2.52 [95%CI:1.42-4.47]). The risk was similar for unprovoked and provoked VTE, and slightly higher in patients with pulmonary embolism (adjusted odds ratio 3.19 [95%CI:1.68-6.09]) than in those with deep vein thrombosis alone (2.29 [95%CI:1.22-4.30]). No interaction between high RDW and thrombophilia abnormalities on the risk of VTE was observed. CONCLUSION: Our findings confirm RDW as an independent and easily available marker for stratification of the risk of VTE.
BACKGROUND: An association between high red cell distribution width (RDW) and venous thromboembolism (VTE) has been observed. However, it is not known whether this association differs within various manifestations of VTE, nor if there is an interaction between RDW and thrombophilia abnormalities on the risk of VTE. AIMS: To investigate whether RDW is a marker of the risk of VTE; to identify subgroups of patients in which the association between RDW and VTE is stronger; to investigate a possible interaction between RDW and thrombophilia abnormalities. METHODS: Case-control study on 730 patients with a first objectively-confirmed VTE episode (300 unprovoked and 430 provoked) consecutively referred to our Center between 2007 and 2013, and 352 healthy controls. Blood was taken for a thrombophilia work-up and a complete blood count, including RDW, at least three months after VTE. RESULTS: Individuals with RDW above the 90(th) percentile (>14.6%) had a 2.5-fold increased risk of VTE compared to those with RDW ≤90(th) percentile, independently of age, sex, body mass index, other hematological variables and renal function (adjusted odds ratio: 2.52 [95%CI:1.42-4.47]). The risk was similar for unprovoked and provoked VTE, and slightly higher in patients with pulmonary embolism (adjusted odds ratio 3.19 [95%CI:1.68-6.09]) than in those with deep vein thrombosis alone (2.29 [95%CI:1.22-4.30]). No interaction between high RDW and thrombophilia abnormalities on the risk of VTE was observed. CONCLUSION: Our findings confirm RDW as an independent and easily available marker for stratification of the risk of VTE.
Authors: Sara Lindström; Lu Wang; Erin N Smith; William Gordon; Astrid van Hylckama Vlieg; Mariza de Andrade; Jennifer A Brody; Jack W Pattee; Jeffrey Haessler; Ben M Brumpton; Daniel I Chasman; Pierre Suchon; Ming-Huei Chen; Constance Turman; Marine Germain; Kerri L Wiggins; James MacDonald; Sigrid K Braekkan; Sebastian M Armasu; Nathan Pankratz; Rebecca D Jackson; Jonas B Nielsen; Franco Giulianini; Marja K Puurunen; Manal Ibrahim; Susan R Heckbert; Scott M Damrauer; Pradeep Natarajan; Derek Klarin; Paul S de Vries; Maria Sabater-Lleal; Jennifer E Huffman; Theo K Bammler; Kelly A Frazer; Bryan M McCauley; Kent Taylor; James S Pankow; Alexander P Reiner; Maiken E Gabrielsen; Jean-François Deleuze; Chris J O'Donnell; Jihye Kim; Barbara McKnight; Peter Kraft; John-Bjarne Hansen; Frits R Rosendaal; John A Heit; Bruce M Psaty; Weihong Tang; Charles Kooperberg; Kristian Hveem; Paul M Ridker; Pierre-Emmanuel Morange; Andrew D Johnson; Christopher Kabrhel; David-Alexandre Trégouët; Nicholas L Smith Journal: Blood Date: 2019-11-07 Impact factor: 25.476
Authors: Tiago D Martins; Joyce M Annichino-Bizzacchi; Anna V C Romano; Rubens Maciel Filho Journal: Clin Appl Thromb Hemost Date: 2019 Jan-Dec Impact factor: 2.389