Mariano Espinosa de Rueda1, Guillermo Parrilla2, Sergio Manzano-Fernández2, Blanca García-Villalba2, Joaquín Zamarro2, Francisco Hernández-Fernández2, Cristina Sánchez-Vizcaino2, Ester Carreón2, Ana Morales2, Antonio Moreno2. 1. From the Service of Interventional Neuroradiology (M.E.d.R., G.P., B.G.-V., J.Z., A. Moreno), Service of Neurology (G.P., C.S.-V., E.C., A. Morales), and Service of Cardiology (S.M.-F.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; and Service of Neurology, Hospital General Universitario de Albacete, Albacete, Spain (F.H.-F.). mm.espinosa@gmail.com. 2. From the Service of Interventional Neuroradiology (M.E.d.R., G.P., B.G.-V., J.Z., A. Moreno), Service of Neurology (G.P., C.S.-V., E.C., A. Morales), and Service of Cardiology (S.M.-F.), Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; and Service of Neurology, Hospital General Universitario de Albacete, Albacete, Spain (F.H.-F.).
Abstract
BACKGROUND AND PURPOSE: Futile recanalization after acute ischemic stroke occurs in almost half of the patients despite optimal angiographic results. Multimodal neuroimaging may help to improve patient's selection but is still dismissed by many interventionalists. Our aim was to evaluate the accuracy of each parameter of multimodal computed tomography (CT) and their combination for predicting futile recanalization after successful thrombectomy. METHODS: We retrospectively reviewed a cohort of consecutive patients with anterior circulation stroke, fully assessable multimodal CT, and successful recanalization. Nonenhanced CT, CT angiography source images, cerebral blood volume (CBV), cerebral blood flow (CBF), and mismatch CBV-CBF maps were studied by Alberta Stroke Program Early CT Score (ASPECTS); collaterals on CT angiography were graded as poor or good (≤50% or >50% of the middle cerebral artery territory). Futile recanalization was defined as modified Rankin Scale score >2 at 3 months despite successful recanalization. RESULTS: One hundred fifty patients were included and 57% of them had futile recanalization. They had lower ASPECTS on nonenhanced CT, CT angiography source images, CBV, CBF, and mismatch CBV-CBF and presented more frequently poor collaterals (all P<0.001). Among them, CBV showed the highest area under the curve (0.83; 95% confidence interval, 0.76-0.88). In multivariate analyses, CT angiography source images ≤5 (odds ratio, 5.1; 95% confidence interval, 1.2-21.9), CBV≤6 (odds ratio, 3.5; 95% confidence interval, 1.2-9.7), and poor collaterals (odds ratio, 8.6; 95% confidence interval, 1.8-41.7) were independent predictors of futile recanalization. A combined score of these 3 parameters added complementary information: 57% of the patients with score-1, 89% with score-2, and 100% with score-3 had futile recanalization. Reclassification analyses indicated that this score improved prediction of futile recanalization. CONCLUSIONS: In this population, a combined multimodal CT score predicted futile recanalization.
BACKGROUND AND PURPOSE: Futile recanalization after acute ischemic stroke occurs in almost half of the patients despite optimal angiographic results. Multimodal neuroimaging may help to improve patient's selection but is still dismissed by many interventionalists. Our aim was to evaluate the accuracy of each parameter of multimodal computed tomography (CT) and their combination for predicting futile recanalization after successful thrombectomy. METHODS: We retrospectively reviewed a cohort of consecutive patients with anterior circulation stroke, fully assessable multimodal CT, and successful recanalization. Nonenhanced CT, CT angiography source images, cerebral blood volume (CBV), cerebral blood flow (CBF), and mismatch CBV-CBF maps were studied by Alberta Stroke Program Early CT Score (ASPECTS); collaterals on CT angiography were graded as poor or good (≤50% or >50% of the middle cerebral artery territory). Futile recanalization was defined as modified Rankin Scale score >2 at 3 months despite successful recanalization. RESULTS: One hundred fifty patients were included and 57% of them had futile recanalization. They had lower ASPECTS on nonenhanced CT, CT angiography source images, CBV, CBF, and mismatch CBV-CBF and presented more frequently poor collaterals (all P<0.001). Among them, CBV showed the highest area under the curve (0.83; 95% confidence interval, 0.76-0.88). In multivariate analyses, CT angiography source images ≤5 (odds ratio, 5.1; 95% confidence interval, 1.2-21.9), CBV≤6 (odds ratio, 3.5; 95% confidence interval, 1.2-9.7), and poor collaterals (odds ratio, 8.6; 95% confidence interval, 1.8-41.7) were independent predictors of futile recanalization. A combined score of these 3 parameters added complementary information: 57% of the patients with score-1, 89% with score-2, and 100% with score-3 had futile recanalization. Reclassification analyses indicated that this score improved prediction of futile recanalization. CONCLUSIONS: In this population, a combined multimodal CT score predicted futile recanalization.
Authors: Nerses Sanossian; Katherine A Fu; David S Liebeskind; Sidney Starkman; Scott Hamilton; J Pablo Villablanca; Adrian M Burgos; Robin Conwit; Jeffrey L Saver Journal: J Neuroimaging Date: 2016-06-14 Impact factor: 2.486
Authors: Won Hyung A Ryu; Michael B Avery; Navjit Dharampal; Isabel E Allen; Steven W Hetts Journal: J Neurointerv Surg Date: 2016-11-09 Impact factor: 5.836
Authors: De-Cai Tian; Kaibin Shi; Zilong Zhu; Jia Yao; Xiaoxia Yang; Lei Su; Sheng Zhang; Meixia Zhang; Rayna J Gonzales; Qiang Liu; DeRen Huang; Michael F Waters; Kevin N Sheth; Andrew F Ducruet; Ying Fu; Min Lou; Fu-Dong Shi Journal: Ann Neurol Date: 2018-11-02 Impact factor: 10.422