Patompong Ungprasert1,2, Charat Thongprayoon3, Wonngarm Kittanamongkolchai3, Narat Srivali4, Wisit Cheungpasitporn3. 1. Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA. 2. Department of medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. 3. Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA. 4. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Abstract
AIM: To investigate the association between giant cell arteritis (GCA) and risk of peripheral arterial disease (PAD). METHODS: We conducted a systematic review and meta-analysis of observational cohort studies that reported relative risks, hazard ratios or standardized incidence ratios with 95% confidence comparing PAD risk in patients with GCA versus non-GCA subjects. Pooled risk ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance of DerSimonian and Laird. RESULTS: Four studies with 9789 patients with GCA and 236 728 controls were identified and included in our data analysis. The pooled risk ratio of PAD among patients with GCA compared with controls was 1.88 (95% CI 1.04-3.41). The statistical heterogeneity was high with an I(2) of 89%. CONCLUSION: Our study demonstrated a statistically significant increased risk of PAD among patients with GCA.
AIM: To investigate the association between giant cell arteritis (GCA) and risk of peripheral arterial disease (PAD). METHODS: We conducted a systematic review and meta-analysis of observational cohort studies that reported relative risks, hazard ratios or standardized incidence ratios with 95% confidence comparing PAD risk in patients with GCA versus non-GCA subjects. Pooled risk ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance of DerSimonian and Laird. RESULTS: Four studies with 9789 patients with GCA and 236 728 controls were identified and included in our data analysis. The pooled risk ratio of PAD among patients with GCA compared with controls was 1.88 (95% CI 1.04-3.41). The statistical heterogeneity was high with an I(2) of 89%. CONCLUSION: Our study demonstrated a statistically significant increased risk of PAD among patients with GCA.
Authors: Max Yates; Robert Luben; Shabina Hayat; Sarah L Mackie; Richard A Watts; Kay-Tee Khaw; Nick J Wareham; Alex J MacGregor Journal: Rheumatology (Oxford) Date: 2020-02-01 Impact factor: 7.580