Alba Lubeiro1, Cristina Rueda2, Juan A Hernández3, Javier Sanz4, Fernando Sarramea5, Vicente Molina6. 1. Department of Psychiatry, Clinical University Hospital of Valladolid, University of Valladolid, Spain. 2. Statistics Department, University of Valladolid, Spain. 3. University Rey Juan Carlos, Medical Imaging Laboratory, Madrid, Spain. 4. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain; Department of Psychiatry, Hospital 12 de Octubre, Madrid, Spain. 5. Department of Psychiatry, Hospital Reina Sofía, Córdoba, Spain. 6. Department of Psychiatry, Clinical University Hospital of Valladolid, University of Valladolid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. Electronic address: vicente.molina@uva.es.
Abstract
BACKGROUND: Several biologically distinct subgroups may coexist within schizophrenia, which may hamper the necessary replicability to translate research findings into clinical practice. METHODS: Cortical thickness, curvature and area values and subcortical volumes of 203 subjects (121 schizophrenia patients, out of which 64 were first episodes), 60 healthy controls and 22 bipolar patients were used to identify clusters using principal components and canonical discriminant analyses. Regional glucose metabolism using positron emission tomography, P300 event related potential, baseline clinical data and percentage of improvement with treatment were used to validate possible clusters based on MRI data. RESULTS: All the controls, the bipolar patients and most of the schizophrenia patients were grouped in a cluster (cluster A). A group of 24 schizophrenia patients (12 first episodes), characterized by large intrinsic curvature values, was identified (cluster B). These patients, but not those in cluster A, showed reduced thalamic and cingulate glucose metabolism in comparison to controls, as well as a worsening of negative symptoms at follow-up. Patients in cluster A showed a significant putaminal metabolic increase, which was not observed for those in cluster B. P300 amplitude was reduced in patients of both clusters, in comparison to controls. CONCLUSIONS: Results of this study support the existence of a biologically distinct group within the schizophrenia syndrome, characterized by increased cortical curvature values, reduced thalamic and cingulate metabolism, lack of the expected increased putaminal metabolism with antipsychotics and persistent negative symptoms.
BACKGROUND: Several biologically distinct subgroups may coexist within schizophrenia, which may hamper the necessary replicability to translate research findings into clinical practice. METHODS: Cortical thickness, curvature and area values and subcortical volumes of 203 subjects (121 schizophreniapatients, out of which 64 were first episodes), 60 healthy controls and 22 bipolarpatients were used to identify clusters using principal components and canonical discriminant analyses. Regional glucose metabolism using positron emission tomography, P300 event related potential, baseline clinical data and percentage of improvement with treatment were used to validate possible clusters based on MRI data. RESULTS: All the controls, the bipolarpatients and most of the schizophreniapatients were grouped in a cluster (cluster A). A group of 24 schizophreniapatients (12 first episodes), characterized by large intrinsic curvature values, was identified (cluster B). These patients, but not those in cluster A, showed reduced thalamic and cingulate glucose metabolism in comparison to controls, as well as a worsening of negative symptoms at follow-up. Patients in cluster A showed a significant putaminal metabolic increase, which was not observed for those in cluster B. P300 amplitude was reduced in patients of both clusters, in comparison to controls. CONCLUSIONS: Results of this study support the existence of a biologically distinct group within the schizophrenia syndrome, characterized by increased cortical curvature values, reduced thalamic and cingulate metabolism, lack of the expected increased putaminal metabolism with antipsychotics and persistent negative symptoms.
Authors: Junhao Wen; Erdem Varol; Aristeidis Sotiras; Zhijian Yang; Ganesh B Chand; Guray Erus; Haochang Shou; Ahmed Abdulkadir; Gyujoon Hwang; Dominic B Dwyer; Alessandro Pigoni; Paola Dazzan; Rene S Kahn; Hugo G Schnack; Marcus V Zanetti; Eva Meisenzahl; Geraldo F Busatto; Benedicto Crespo-Facorro; Romero-Garcia Rafael; Christos Pantelis; Stephen J Wood; Chuanjun Zhuo; Russell T Shinohara; Yong Fan; Ruben C Gur; Raquel E Gur; Theodore D Satterthwaite; Nikolaos Koutsouleris; Daniel H Wolf; Christos Davatzikos Journal: Med Image Anal Date: 2021-11-11 Impact factor: 8.545
Authors: Dominic B Dwyer; Madalina-Octavia Buciuman; Anne Ruef; Joseph Kambeitz; Mark Sen Dong; Caedyn Stinson; Lana Kambeitz-Ilankovic; Franziska Degenhardt; Rachele Sanfelici; Linda A Antonucci; Paris Alexandros Lalousis; Julian Wenzel; Maria Fernanda Urquijo-Castro; David Popovic; Oemer Faruk Oeztuerk; Shalaila S Haas; Johanna Weiske; Daniel Hauke; Susanne Neufang; Christian Schmidt-Kraepelin; Stephan Ruhrmann; Nora Penzel; Theresa Lichtenstein; Marlene Rosen; Katharine Chisholm; Anita Riecher-Rössler; Laura Egloff; André Schmidt; Christina Andreou; Jarmo Hietala; Timo Schirmer; Georg Romer; Chantal Michel; Wulf Rössler; Carlo Maj; Oleg Borisov; Peter M Krawitz; Peter Falkai; Christos Pantelis; Rebekka Lencer; Alessandro Bertolino; Stefan Borgwardt; Markus Noethen; Paolo Brambilla; Frauke Schultze-Lutter; Eva Meisenzahl; Stephen J Wood; Christos Davatzikos; Rachel Upthegrove; Raimo K R Salokangas; Nikolaos Koutsouleris Journal: JAMA Psychiatry Date: 2022-07-01 Impact factor: 25.911
Authors: Javier Gomez-Pilar; Rodrigo de Luis-García; Alba Lubeiro; Henar de la Red; Jesús Poza; Pablo Núñez; Roberto Hornero; Vicente Molina Journal: Hum Brain Mapp Date: 2018-04-02 Impact factor: 5.038
Authors: Inés Fernández-Linsenbarth; Álvaro Planchuelo-Gómez; Rosa M Beño-Ruiz-de-la-Sierra; Alvaro Díez; Antonio Arjona; Adela Pérez; Alberto Rodríguez-Lorenzana; Pilar Del Valle; Rodrigo de Luis-García; Guido Mascialino; Pedro Holgado-Madera; Rafael Segarra-Echevarría; Javier Gomez-Pilar; Pablo Núñez; Berta Bote-Boneaechea; Antonio Zambrana-Gómez; Alejandro Roig-Herrero; Vicente Molina Journal: Brain Behav Date: 2021-11-10 Impact factor: 2.708